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HLA DR for Lyme

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Posted 5/20/2020 5:02 PM (GMT 0)
Hi there!
I plan to do control lab tests in amazing Germany lab IMD - they have lot of great tests!

They have also lot of LTT testing - this is nothing new, but what interested me is gene test "HLA DR" for Boreliosis.
Check here under infection diagnosis: https://www.imd-berlin.de/fileadmin/user_upload/Anforderungsscheine/en/Spez_Immundiagnostik_engl.pdf

Did anyone this gene test and it was beneficial for them? does anyone have more information on whether it's worth the money? My case is severe CFS for which it is not certain whether it is caused by Lyme, whose activity in my case is uncertainty for years.

What can HLA DR show? Thanks! smile
Martin
Posted 5/20/2020 5:08 PM (GMT 0)
I have the "dreaded genes" for Lyme, mold, etc. It was not helpful for me to find out. I still can get better, but it will be tougher than it might be for someone without the genetic predisposition. From my experience with treatment, the difficulty was already obvious! But I'd be curious to hear if others found the genetic testing useful.
Posted 5/20/2020 5:28 PM (GMT 0)
I have the hla gene for lyme. Not really helpful for me to find out. I’ve had many docs think mold is my issue despite not having the mold gene.
Posted 5/20/2020 6:51 PM (GMT 0)

MartinK said...
Hi there!
I plan to do control lab tests in amazing Germany lab IMD - they have lot of great tests!

They have also lot of LTT testing - this is nothing new, but what interested me is gene test "HLA DR" for Boreliosis.
Check here under infection diagnosis: https://www.imd-berlin.de/fileadmin/user_upload/Anforderungsscheine/en/Spez_Immundiagnostik_engl.pdf

Did anyone this gene test and it was beneficial for them? does anyone have more information on whether it's worth the money? My case is severe CFS for which it is not certain whether it is caused by Lyme, whose activity in my case is uncertainty for years.

What can HLA DR show? Thanks! smile
Martin

Have you tested positive for lyme previously?
Posted 5/20/2020 7:13 PM (GMT 0)
Mine was fine except for a suggestion of MSH susceptibility when it drops below ten. When the happens the vulnerability to mold is similar as a mold vulnerable MSH. My MSH was 9 lol how did it drop then? I have no clue.

Anyways, this test is rather controversial so I wouldn’t let it change anything.
Posted 5/20/2020 7:48 PM (GMT 0)
Yes. I have the Lyme gene and one of the “dreaded” multi susceptible genes. It was beneficial to me to know that there’s a genetic component that helps explain why I got so sick while others didn’t. It also helps me be more aware of potential exposure to other sources of biotoxins such as blue-green algae.

Having a multi-susceptible gene makes me vulnerable. I have always felt vulnerable to unseen things in the environment and lived cautiously based on my natural instincts, Having some knowledge of what is a potential threat is helpful to me, and knowing that those “feelings” had a real basis that was simply undiscovered at the time makes me feel better and more confident about trusting my instincts without facts or proof.

My insurance covered my test.

I believe there are some other things besides the CIRS issues that can be at least partly mined from the data, like Alzheimers.

Post Edited (WalkingbyFaith) : 5/20/2020 1:52:26 PM (GMT-6)

Posted 5/21/2020 5:43 PM (GMT 0)
Hi there, I was tested positive in past, its been a really long time, when I had Lyme first time.
I ask, therefore, whether the HLA DR test to clarify whether I am still positive, or whether it only points if the treatment is more problematic if it got still positive.

I don't really understand gene testing, I don't know if I can spend money on it except LLT testing.

What does the HLA DR result look like?

Thanks, cheers Martin
Posted 5/23/2020 11:54 AM (GMT 0)
MartinK: The LTT at IMD was what gave me my first definitive Lyme diagnosis. The doctor who sent me there laughed at the standard tests used in the US - and with god reason.

Saraeli/WalkingbyFaith: What genes/snippets in particular are relevant to Lyme/mold? I had genetic testing done last year but was never really able to make any sense of the results. Sorry for partially derailing the thread, MartinK, but I think this is somewhat related.
Posted 5/24/2020 1:11 PM (GMT 0)
This shows the test to order. HLA is at the top of the list.https://www.survivingmold.com/docs/lab_orders_2017.pdf

The chart indicating the codes for different susceptibles is here. https://www.survivingmold.com/diagnosis/lab-tests

Here’s how to decipher the lab results. http://biotoxinjourney.com/deciphering-hla-dr-labs/

In the biotoxinjourney article, Greg added an update in 2018 regarding the questionability and usefulness of the HLA-DR testing.

“ Update April 29, 2018
In Parasites & CIRS Update, I mentioned that HLA-DR testing has fallen out of favor. In 2017, Dr. Sonia Rapaport presented at the International Conference on Chronic Pathologies. At 10:30 in that presentation, she discusses the fact that the number of people that have a susceptible haplotype is much higher than the 24% reported by Dr. Shoemaker. Race, country, and ethnicity all play a role. For example, 90% of folks in Belgium have at least one “bad” halplotype. Given this, she seriously questioned the usefulness of HLA-DR testing.

Sean also points out that in the 2016 Irvine Mold Conference that Dr. Shoemaker himself commented that HLA-DR testing is questionable. I don’t have those videos, but I do have notes that others took of the conference. At that time, Dr. Rapaport was already looking into HLA-DR.”

Post Edited (WalkingbyFaith) : 5/24/2020 7:23:50 AM (GMT-6)

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