Bad sleep with Disulfiram? Read this.

I know there is a disulfiram thread but I thought this could use its own thread since I've heard several people mention disturbed sleep on disulfiram.

I found this study:

Sleep impairment by diethyldithiocarbamate in rat. Protective effects of pre-conditioning and antioxidants

(diethyldithiocarbamate is a dithiocarbamate, which is a class of compounds that disulfiram belongs to)

"On the other hand, when the higher dose of DDTC was given in association with either one of two antioxidants, α-tocopherol or melatonin, the amounts of SWS and PS significantly improved even on day 1, suggesting that the DDTC effects on sleep involved an impairment of the brain oxidative balance. "

https://docdro.id/7vdasrt

This means that Vitamin E or Melatonin might help us. I'm going to try melatonin tonight, I will report back!

Post Edited (RainyCloud) : 7/18/2020 12:36:38 PM (GMT-6)

This is so interesting, since for me melatonin gives me nightmares! I seem to be odd in that regard, though. Good tip for the folks on disulfiram! Not sleeping is so hard.

Another update:

I had even more improvement (~70%) this last night with taking melatonin.

Just a bit more and I'll have a good nights sleep again.

Thank you Girlie!
I feel like Melatonin has sleep benefits which its known for, but with disulfiram it actually improves sleep by acting as an antioxidant, which is an interesting mechanism.

Post Edited (RainyCloud) : 7/16/2020 10:59:59 AM (GMT-6)