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Nattokinase and fatigue?

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Posted 10/28/2020 5:09 PM (GMT 0)
I recently tried taking nattokinase again and it seems to trigger strong fatigue. Even just taking a single dose in the morning which seems really surprising to me. Anyone find they react to it that quickly? Just a co-incidence or my imagination lol?

I took serrapeptase a few weeks a year or two ago on two separate occasions and stopped due to an increase in nerve pain and tingling figuring it was stirring up too much at that time.

I took a round of nattokinase early in this year for almost two months with no noticeable changes. It’s one of the reasons I thought I was approaching remission and slowly started tapering things down.

I was surprised by my response this time so I guess I have rather a lot of Lyme lurking in the corners to deal with after all. Still I’m surprised by the quick reaction so thought I’d ask to see if anyone else found this too.
Posted 10/28/2020 5:23 PM (GMT 0)
Lumbrokinase, which is similar, caused extreme weakness and lightheadedness. I was on it for a month and couldnt get off the couch. Just assumed i was getting POTS until i realized it was the lumbro, probably thinning my blood. It stopped immediately after stopping lumbro.
Posted 10/28/2020 9:23 PM (GMT 0)
I actually had trouble sleeping while on natto.. especially when I took it in the afternoon or evening. I don't think it affected my energy levels one way or the other though.
Posted 10/28/2020 10:40 PM (GMT 0)
While on the subject I've been wanting to try natto really bad bt it comes from like Chinese soy beans or something I've read. Wondering if I can take it if I'm allergic to soy? Then again being allergic to soy and everything else due to my lyme and mcas idk?
Posted 10/29/2020 1:53 AM (GMT 0)
Interesting. I have been wanting to try one or all these and still haven’t. Lumbro is supposed to be the strongest. I really want to try that one.
Posted 10/29/2020 11:36 AM (GMT 0)
this has been on my list to try for a while now also ( its a long list! lol)

mainly because i have what seems to be microcirculation issues and suspected Bart which tends to cause lots of fibrin deposits which nattokinase is supposed to be very specific for and does not affect other clotting factors or blood chemistry.

i took one capsule of Now foods Nattokinase 2000gdu a few days ago - on an empty stomach mid-morning as a trial. ( edit - it was Drs Best Brand Nattokinase|)

i had chosen a period where most things were stable and wasn't really expecting anything dramatic from one capsule - but i had quite a few signs of gut symptoms starting around 45mins afterward and worsening for a few hours and lasting for the rest of that day. i was a bit off-color, maybe a bit more fatigue than normal - but mainly just ggut symptoms = cramps, knots, gurgling, mild to moderate sharp pains.

it had been my intention to start at this low dose of one capsule and work my way up - but its was quite an impact on my day and think I would have to start at something like 1/5 of a capsule or less and work my way up from there for it to be tolerable.

would need to figure a way of doing that - maybe empty the capsule into a weighted amount of something neutral and dose with that? - so i think will shelve it until I find a way around that.

or maybe i will buy a blood oxygen meter and measure the rate of fall of blood oxygen saturation if i hold my breath ( meant to be a quick way of detecting fibrin deposits - as they slow the uptake of oxygen by cells from the blood - ref Ann Corson et al ) - and so check if fibrin is really an issue 1st before deciding to go through all the hassle and side effect type gut symptoms.

Post Edited (Garzie) : 10/29/2020 6:14:56 AM (GMT-6)

Posted 10/29/2020 12:37 PM (GMT 0)
there is an interesting article here - a better health guy summary of a presentation by Ann Corson ( about 1/2 way down the page )

https://www.betterhealthguy.com/tfim2020

talks about mechanisms of action and says

some brands of nattokinase are fine for people with soy allergy

"30% of the population has some genetic abnormality; hypercoagulators are more likely to develop chronic disease; as many as 95% of chronically ill patients are hypercoagulable.
Symptoms: generalized pain, limbs fall asleep, achy or sharp stabbing shooting pains, neuralgic pain, brain fog, irritable, anxiety, insomnia, restless legs, stiff upon waking, nausea upon waking, poor morning appetite, painful teeth or loose sensation, no aerobic exercise tolerance.
Signs: brain fogged, irritable, mottled skin, tear up several times during appointment, cold/clammy extremities though warm centrally, pale swollen tongue with scalloped edges, peri-umbilical tenderness, tissue congestion, feet can be deep purple, poor capillary refill."

"PT/PTT can indicate hypercoagulation; SED rate being low (<5) can indicate hypercoagulation."

i have tested like this - also have a poor capillary refill and many of the signs above

there was a study recently ( and a post on the forum i think ) that found a very high % of Lyme patients also have some form of hughes syndrome - or antiphospholipid syndrome - which is linked to hypercoagulation.
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