Cell danger response

Has anyone suspected an active cell danger response similar to what Neil Nathan describes, and treated it with Lysine and B6 like he mentions and had success?

Is the CDR only implicated in mold/CIRS, or can infections cause it?

How else can you treat it?

-FLOG

You could e-mail Dr. Naviaux and ask him directly.

https://pubmed.ncbi.nlm.nih.gov/23981537

In the above article, look under the title. You should see his name listed: Robert K Naviaux. Under his name, click "+ expand" and you will find his e-mail address. I'm pretty sure he would be happy to answer a question or two -- especially from someone dealing with chronic illness.

Spent the morning reading about this. Here is the paper NN refers to:
https://www.researchgate.net/publication/256187876_metabolic_features_of_the_cell_danger_response

He does indeed mention lysine and b6 as two supplements that oppose the CDR.

If the literature and theories are correct, it is maintained by purinergic signalling. The cells eschew ATP in an effort to shut down their metabolism such that the invading agent cannot replicate. ATP was never believed to be a neurotransmitter, but it now appears that there is evidence that it functions like any another neurotransmitter such as glutamate and acetylcholine.

I've been curious about glutamate's role in sensory neuropathy. This just adds another layer to the onion.

It appears that P2X2 and P2X3 are the ATP receptors found in sensory neurons.

According to Wiki:

Allosteric modulation
The sensitivity of P2X receptors to ATP is strongly modulated by changes in extracellular pH and by the presence of heavy metals (e.g. zinc and cadmium). For example, the ATP sensitivity of P2X1, P2X3 and P2X4 receptors is attenuated when the extracellular pH<7, whereas the ATP sensitivity of P2X2 is significantly increased. On the other hand, zinc potentiates ATP-gated currents through P2X2, P2X3 and P2X4, and inhibits currents through P2X1. The allosteric modulation of P2X receptors by pH and metals appears to be conferred by the presence of histidine side chains in the extracellular domain. In contrast to the other members of the P2X receptor family, P2X4 receptors are also very sensitive to modulation by the macrocyclic lactone, ivermectin.[33] Ivermectin potentiates ATP-gated currents through P2X4 receptors by increasing the open probability of the channel in the presence of ATP, which it appears to do by interacting with the transmembrane domains from within the lipid bilayer.[34]

Suprising that Zinc could make this worse, but I did notice from my notes that I got what I thought were increased excitatory headaches (i assumed glutamate) shortly after high doses of zinc. Will experiment with zinc to see if that was true or not.

Post Edited (dcd2103) : 12/31/2020 9:33:07 AM (GMT-7)

Thanks saraeli. NN says that methylation can be detrimental if done too early. Seems to be my experience. But will look into those others.

I want to try limbic retraining again. Have you heard of Dr Joe Dispenza? Saw a woman who beat her CIDP, contacted her last night. She says that his program is what did it. Think its simlar to hopper's/guptas

Watching the video you linked to now, thanks!

Post Edited (dcd2103) : 12/31/2020 9:39:57 AM (GMT-7)

Ah interesting. That doesnt sound very appealing to me. I used Wim Hof for about 3m, which as you prob know is a form of hyperventilation with ice baths. Although I loved doing it, i would do it every day if i could, i found that it made me worse. Similar to this CDR idea, i felt that my body just wasnt ready for it.

Any idea if there are specific telltale symptoms of CDR?

astroman said...
Interesting post somehow I didn’t see this yesterday. I was not aware that sell danger response was the term given to this theory at least it’s something you can Google now.

I just called this the “vicious chronic circle” , as I’m sure that many here can relate to what that refers to.

I’d really like to google the heck out of this right now but I told my brain I take a day off and veg on this New Year’s Day.

Many People who are in Lyme remission, Still have a small percentage of symptoms kind of a reminder of what was once there. Obviously most people will take 90% healed any day but 100% would certainly be nice. It’s like the cell danger response is not fully turned off and is there just waiting to be activated again , that’s the best I can describe it.

As far as a simple treatment for it mentioned here B6 and lysing , Those were no magic supplements for myself.

I wonder if the fact that some people here and outside of the lyme world with chronic conditions easily build up higher unsafe levels of B6 in their blood Has a connection to this.

Yup, in the video that saraeli posted Neil Nathan goes on to say that he now believes that lysine and b6 are probably not that helpful, and that the only way to fix the problem is to remove the toxic insult in the first place. This helped motivate me to finally take the plunge and try NBMI. It was near the top of my list already.

The only pharmacological intervention with any merit seems to be the anti-purinergic Sumarin. Of course, its not legal in the US. NN mentions how chinese skullcap has some anti-purinergic properties, and may be useful.