OAT HELP

This must be a different lab than Great Plains. I just looked over mine again.

My glutathione indicators were terrible, even though I was supplementing liposomal glutathione daily around 1275 mg. My NAC levels were also zero even though I supplemented 1,200 mg per day for years.

The lab gave notes under the glutathione section that said this:

“High 2-hydroxybutyric acid (Marker 59) This organic acid is elevated when there is increased production of sulfur amino acids derived from homocysteine. The reasons for an increase can be due to the following reasons (which are not mutually exclusive):
1. There is increased need for glutathione to detoxify a host of toxic chemicals, resulting in increased shunting of homocysteine into the production of cysteine for glutathione. This is the most common reason.
2. There are genetic variants of the DNA such that methylation of homocysteine by betaine homocysteine methyl transferase or methionine synthase is impaired.
3. There are nutritional deficiencies of betaine, methylcobalamin, or methyltetrahydrofolate that reduce the enzyme activities of the enzymes in #2 above.
4. There is a genetic variant in cystathionine beta synthase (CBS) enzyme such that there is excessive shunting of homocysteine into cysteine production that results in excessive 2-hydroxybutyric acid formation.”

Unfortunately, it didn’t offer treatment suggestions for this like it did for some other things.

If #1 or #4 are the case, would supplementing cysteine help?

i'm no expert DCD - i went through some of this stuff to understand my own OAT ( Great plains lab - so different)
however i had some different markers to you out of range - so did different research - not all applicable here.

anyway - a couple of points i would make

the citric acid cycle is all to do with energy production - strictly from all sources - eg Carbs, Fats, and Proteins
however - in your case, it will be predominantly from fats as i think you are sticking to a fairly strict Keto diet - and my thoughts are - understanding how the normal ranges are established - it will be the mean and 1-2 standard deviation on either side approach - based on 1000 test subjects
( as an aside i didn't grasp exactly how the genova test is representing its results - ie is the scale linear - or standard deviations around the mean ...?)

anyway, due to keto being such a rare and by conventional thinking - extreme diet - it's possible this is the main reason for the outside normal range results here.
if your energy levels are OK - i would not worry

if they are not OK - and you are eating enough calories - then maybe look into adding energy production cofactors to your protocol. the main ones i think are B vitamins, CoQ10, Acetyl-L-Carnitine, magnesium
( i think this is the red text on the section means ) I think these have helped me - especially ALC

b-vitamins - most are made by the gut bacteria - so I would guess dysbiosis could be at the root of that - or poss malabsorption due to inflammation in the gut - not sure what else you can do other than to supplement / or maybe try to feed the ones that make those you are short of.

neurotransmitters - low serotonin - high kynurenate tend to go together i think as they are two sides of the same pathway - ie two end products of the tryptophan pathway - inflammation in the CNS tends to swing the balance to create more kynurenate and result in less serotonin i think. infection is one known cause - but there are likely others. it's associated with neuron excitotoxicity I think.

This is some explanation of the pathway in the Great plains labs OAT sample report - i had v high quinolinic acid markers - which is the end product on the bad side of the tryptophan pathway - but i don't see that on your test - but it may be suggested by the high kynurenate low serotonin. they also take ratios of several of these end products as indicators of which way the pathways are biased - which i think is a useful approach. but again i don't see that on the genova one
see page 10 and page 7 here for more info on the neurotransmitters
https://www.biolab.co.uk/docs/organicacidsrep.pdf

also, there is a half-decent interpretation guide for the various bits of the OAT on this site -

https://drjockers.com/organic-acids-test-functional-health/

Garzie,

Thank you so much for that link. Extremely helpful. Best explanation I have seen. My doctor basically read me the lab report.🙄

I really would like to do this again. I had it done in June 2019, just before I moved into my car and started antifungals. When I mentioned retesting last year, my doctor wasn’t interested.

Just got my results from the Great Plains Oat test. Everything was fine pretty much except for 3 different markets for yeast.

Curious if anyone else out there had this test run and did they show for yeast? Compared notes w a friend who had the same exact 3 markers. Curious if this is clinically significant or do these markers just randomly pop up in everyone or healthy people too

Problem is I can’t handle any anti-candida herbs. Have tried Berberine, oil of oregano, and GSE and all 3 make me burn. Clearly 6m of near zero carbs was not enough to starve the yeast out either

Hi guys!
I also thinking about OAT test. What do you prefer - Great Plain Labs or Genova?
Is there an alternative in Europe?

So that the sample does not have to travel across half the world and, for example, suffers from quality during that time.

Thanks for some info ;-)
cheers, Martin

Garzie said...
dcd,
my partner and i both had yeast markers in the great plains OAT on first test - along with lots of microbial overgrowth markers, inflammation markers and oxidative stress markers - at that point we thought we just had dysbiosis -

so we then did 12weeks of a pretty comprehensive herbal protocol
with decent doses of antimicrobial herbs - including berberine containing ones etc ( made us feel absolutely awful btw - could hardly function - it didn't let up and after 12 weeks we had to stop and retest the OAT

yeast markers were gone - and most bacterial markers were back in range - symptoms were still there though ....a part of our journey that eventually led us back towards Lyme.

i too would have hoped 6mo of strict Keto would be enough to clear a yeast overgrowth - but i have heard MD's who specialise in gut stuff say that once established diet alone is not sufficient to address candida/yeast overgrowth. i guess if it can grow on a catheter and become invasive it can grow in the absence of much sugar / carbs

in termsof treatment

i suspect almost any antimicrobial treatment may flare your neuropathy symptoms

maybe nystatin would be tolerated better - as it is supposed to stay in the gut
Dr Myhill is a kind of UK functional medicine MD who specialises in CFS type illnesses - has published a few interesting papers on mitochondrial dysfunction and has a page where she describes using v high doses of nystatin (8 million units a day) safely for yeast.

https://www.drmyhill.co.uk/wiki/yeast_problems_and_candida

she also mentions another newer antifungal that is proving effective - again is not broadly absorbed
so could be a possible
https://www.drmyhill.co.uk/wiki/Lufenuron_-_a_potentially_useful_treatment_to_treat_candida

Thank you for this garzie. I will talk to my LLMD about nystatin, thats a great idea. I may try to do very low doses of black walnut and neem. It's great to hear herbals actually helped yoru candida

I suspect, however, that once i improve my autonimic function at Spero Clinic that htese things willl heal themselves

dcd2103: Thank you for info!
I really thinking about test from Great Plains!

👍 keep up the good fight!!