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Tinidazole peripheral neuropathy

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Posted 6/15/2021 1:09 AM (GMT 0)
I know that peripheral neuropathy can be caused by consuming tinidazole and it can cause permanent damage. I recently started tinidazole and im having some numbness/tingling only in my right leg and right arm (occasionally). However, this is a symptom that I have had from lyme before treatment but since starting the medication, its gotten a bit more intense so im not sure if it is a herx or a source for the peripheral neuropathy. Would the tinidazole associated neuropathy happen in all extremities or what do you guys think it is? I definitely want to wait a few days to see if it will subside. Has anyone had experience with this?
Posted 6/15/2021 1:40 AM (GMT 0)
If you’re having neuropathy from lyme it’s likely inflammatory.

My understanding w tinidazole induced neuropathy is that it’s a toxicity induced neuropathy and occurs at higher doses over longer periods. It usually subsides when you stop the drug, I think.

What is more likely is happening is your inflammatory neuropathy is being aggravated by tindi’s effect on the immune system/herx.

I would not mess w neuropathy. I had low levels of neuropathy until it exploded and now I can’t control it and my life is pretty much ruined. Same thing happened to a friend w Alinia.

I say this only because you don’t mess w neuropathy
Posted 6/15/2021 1:53 AM (GMT 0)
Thanks for your response dcd2103, I am only on 250 mg currently so do you think im okay to stick with the tinidazole for a bit and see when it subsides?Just to clarify, you think its a herx? You said tinidazole induced neuropathy occurs at high doses and I wouldn't consider 250 mg to be that high. The neuropathy im having is the same exact as my lyme symptom just a little bit worse. Its not really painful its more of an annoyance.
Posted 6/15/2021 2:01 AM (GMT 0)
Yup, do some googling on that but I’m pretty sure tindi neuropathy tends to be cumulative dose dependent. I remember when my dr prescribed it he said it would only be a problem if we were on it for longer periods. This makes sense, because I also am quite sure it tends to be a toxic neuropathy. Those tend to be dose dependent and not to be self-perpetuating. You stop the drug and the damage stops and it eventually heals.

It sounds like you’re just aggravating your lyme symptoms. Inflammatory neuropathy is a little scarier because it can become self-perpetuating. So if you start seeing more of an increase definitely stop.

I can’t be sure of any of this, all educated guesses

Post Edited (dcd2103) : 6/14/2021 8:06:16 PM (GMT-6)

Posted 6/15/2021 2:13 AM (GMT 0)
Got it thanks. Im hoping its just a herx. Ill be on the watch for the next week or two. Why would inflammatory neuropathy be bad if its just a herx?
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