Contact allergy if skin touched is fine?

So I mixed a tiny bit of a gaba capsule in water. Then sort of accidentally dripped some on my leg. I wiped it off almost right away. Literally it was a drop. The place where I dripped on my leg is totally fine, but I started feeling all these things both positive and negative. It did what I would expect of gaba in many ways (increased circulation, dropped bp, seemed to help sound sensitivity) but also gave me stomach pain made my tongue tingle and sort of made me want to puke. All of these can be explained by just the actions of gaba, but to make sure it’s not an allergic reaction. My body felt sort of mad, but leg spot was very much not irritated at all. Body might be mad because gaba drops bp and makes me debilitated which can give me that stressed feeling which can lead to allergic feeling.

I took some extra xyzal and mangosteen snd they seemed to help which does that mean it was an allergy? But then would one place this thing touched me be totally fine?

Thoughts?

Post Edited (Bailey) : 7/18/2021 12:48:28 PM (GMT-6)

The one other time I took gaba is crashed my bp. At that time I didn’t have concerns I have now so gave up on it. Either way it appears my blood brain barrier lets all sorts of things in.

Haha yes thanks dcd 🤣, thanks for responding quickly, I’m kind of freaking out even if the gaba is definitely having semi calming effects... my heart rate even went down as my midodrine wore off,.... now I’m sleepy. My body does seem less angry now that I took the midodrine that had worn off. Sighs

Ok looks like docs prescribe the supplement in doses between 1-4 times a day.... so maybe I’ll be sane in like 8 hours ? Hahahaa, ok not sane, but closer to my regular self.

Nope, I opened capsule early in day replaced cap put it back in bottle partition snd mixed it in water that sat on my tray for like half the day with q tip in it because I wasn’t bright and first thought I’ll do this very gently with a q tip and didn’t think hey qtip rod is made of cardboard it’ll soak up fluid if it’s left in it.

Then later I was like eh I don’t think I should experiment because I have appointment with new doc on Wednesday. So I’ll throw it out before it spills, then I grab qtip realize it’s absorbed gaba water and think what the heck it touched my finger (unless gaba didn’t make it up to a tip top with water), why not gently Dab it on my leg.

And what happened next has already been posted. Thanks for half life. I did realize my midodrine had worn off and my singulair a couple hour before I accidentally semi took gaba. Taking midodrine made basically all the Body “i hate you” symptoms go away. So maybe I can blamed the negatives on bad timing and forgetting meds? Sighs

Sorry you’re tired no longer sunshine rainycloud. If you’re anything like me you can I dunno sniff a gaba bottle and maybe get your sunshine back 🤣

Thanks garzie! Yeah I used pure encapsulation gaba which had some oil maybe in it? Maybe that’s how it crossed over? I’m not sure. I did order l theanine.

Post Edited (Bailey) : 7/19/2021 4:39:29 PM (GMT-6)

Hi Bailey!

Hope you're doing well!

With a few exceptions, it's not that easy for supplements to absorb through the skin.
And when they do, it usually takes relatively larger amounts and they would have to stay on your skin for a while.

Amino acids such as L-theanine are hydrophilic and can't pass through the skin without a carrier.
If it has a carrier it would be mentioned that it's transdermal and it would be a cream, lotion or something similar.

Bailey said...
So I think I looked this up and it seemed to be true but you guys are better researchers than me so I’ll ask anyways. If there’s trace histamine on a l theanine supplement it shouldn’t make it through my skin unless I have a skin cut right ?

Of course given what just happened with gaba, who knows if my skin is behaving normally 😭

but my point was that - even if you could absorb 100% of what you spilled on your leg - it would be 100ths or 1000ths of the therapeutic dose - so unlikely that would drive any measurable effect

add in the fact that skin absorption is v inefficient - and you are into the order of another 100x smaller dose still - so the possibility of it driving symptoms seems v remote indeed

at least that would be my rational take on it