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Methylation pathways

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Posted 7/19/2021 3:01 PM (GMT 0)
I'm seriously thinking I may have MTHFR gene because I seem to be detoxing loads and still have a little trouble although over never had this gene tested. Anyhow I read u can increase folate and b12 to increase methylation pathways to detox and also choline.ive never heard of choline anyone try it? Also what were your symptoms of MTHFR gene if anyone has had it and how did u fix it , increase detox??
Posted 7/19/2021 3:14 PM (GMT 0)
I have double MTHFR. I can't handle methylfolate or many methyldonors (methyl b12 is one that is well tolerated for example, so is TMG, whereas SAMe or methylfolate will drive me nuts). Many of us cant. Phosphyditylcholine is methyl-sparing, so acts like a methyldonor. They all causes agitation and insomnia for me. Some of us can handle them, so cant. I think it has to do w/ how sick you are. If the brain chemistry is too depressed for too long, it has to be done gradually and naturally. Forcing the methylation cycle open is more than it can handle. Sometimes what the body lacks and needs the most, it can't handle. I'd suggest starting with some phosphyditylcholine and see if it affects your sleep or anxiety. If it doesnt, you can try methylfolate. If they do, stay away for now.

Post Edited (dcd2103) : 7/19/2021 9:24:12 AM (GMT-6)

Posted 7/19/2021 4:29 PM (GMT 0)
Here's an article that sums up well what my LLMDs have thought about MTHFR: https://vitalplan.com/blog/methylation-what-you-need-to-know

The "mutation" is very common. (I put it in quotes because if almost half of the population has something, do we need to consider it a mutation instead of just normal variation?) I have it, according to testing with one of my first chronic illness doctors, but honestly I don't remember if I have single or double copies. I tolerate all the forms of all the B vitamins the same way - fine - which is rare for me. I take this supplement about twice per week: https://www.vitacost.com/jarrow-formulas-methyl-b12-methyl-folate-plus-p-5-p-b6

That said, dcd is right that everyone reacts differently, and starting anything slowly is a good plan!
Posted 7/19/2021 9:59 PM (GMT 0)
I don't know if I have a MTHFR gene mutation, but blood tests repeatedly found too much homocysteine. Taking hydrocortisone to suppress adrenaline production did get it down, but my doctor was concerned that I might be taking too much hydrocortisone (cortisol came up borderline high on the blood tests). Also carnitine synthesis relies on the same methylation pathway, and supplementing carnitine so that my body doesn't have to produce it seemed to help.
Posted 7/19/2021 10:50 PM (GMT 0)
How does hydrocortisone lower homocysteine? Never heard of that
Posted 7/20/2021 12:18 AM (GMT 0)
Homocysteine is a byproduct of the methylation pathway, which is involved in the synthesis of epinephrine, carnitine, and some other things.

Suppressing the adrenals by taking lots of hydrocortisone lessens production of epinephrine, thus less homocysteine as a byproduct. I suspect alpha-agonists might work too.

And similarly, less production of carnitine reduces the amount of homocysteine as a byproduct.
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