An aha moment

Vitamin B6 and MTHFR
The vitamins B12, B6, and folate are vital in developing and maintaining function of the brain. Deficiency in these vitamins at any stage of the life cycle has been linked to psychiatric and neurologic diseases, but exactly how a deficiency causes this is uncertain. The relationship between B vitamins and neurological diseases are thought to stem from polymorphisms which regulate B vitamin-associated biochemical pathways. The polymorphisms may cause biochemical pathways to either compensate for a deficiency reducing symptoms or provide protection during low intake, further compounding the link to cognitive dysfunction.

The function of vitamin B6
Vitamin B6 is one of the eight water-soluble B vitamins and is known as Pyridoxine as an alcohol, pyridoxal as an aldehyde and pyridoxamine which contains an amino group. The active coenzyme forms of vitamin B6 are pyridoxal 5’ phosphate (PLP), pyridoxine 5’ phosphate and pyridoxamine 5’ phosphate (PMP). These compounds are involved in more than 100 metabolic reactions predominantly involving protein synthesis, more notably haemoglobin synthesis.

Vitamin B6 plays an important role in the metabolism of carbohydrates, fats and protein. One of the more important functions of B6 is its role in the production of neurotransmitters, chemicals that carry signals between synapses, from nerve cell to nerve cell. This is crucial for normal brain development and function. B6 is also responsible for aiding the body in producing serotonin and norepinephrine, important chemicals that influence mood and the circadian rhythm, respectively. Additional neurotransmitters produced include glycine, D-serine, glutamate, histamine and y-aminobutyric acid.

B6 in conjunction with vitamins B12 and B9, have been found to influence and lower the levels of homocysteine in the blood, where higher levels of homocysteine circulating in the blood are thought to increase the risk of cardiovascular disease, and possibly other diseases such as osteoporosis and Alzheimer disease.

Sorry to post long, bt long story short, my blood test came bk really elevated for b6 and my doc had asked him I'm taking b supplements which I absolutely was not back then. Plus despite me trying to detox seems I still have a hard time. Is it safe to say I just might have MTHFR gene? Has anyone else had elevated b6 and wasnt taking supplements, as I have no other reasons to have high b6

Mine came back elevated a couple times but i really may have been supplementing, i couldnt remember.

How high were your levels? WHat are your symptoms?

Here’s a thread on b6 toxicity

https://www.healingwell.com/community/default.aspx?f=30&m=4011476&p=2

Well its not that folic acid is turning into b6 or anything like that. It's that if you have MTHFR you cant turn folic acid into methylfolate. And apparently at that point the folic acid can actually begin to block the sparse methylfolate you've consumed in your diet. So your methyl-cycle slows down and b6 builds up since its not being used, i think is the mechanism, but dont quote me.

Have you tried to supplementing w/ methyl-b12 and methylfolate to get your methylcycle going? Some people cant handle this as it causes agitation and insomnia, at which point you can try creatine.

Girlie said...

MedicalNerd said...
Hey guys so I know high b6 can indeed be caused by folic acid rather than folate since folic acid it synthetic and can build up in our bodies (when u have the MTHFR gene) that was my only known cause, or like someone said bart. Is there anyway to remove the b6 from our bodies since we arent even taking b6 to begin with?

High B6 can be caused by folic acid intake?

I rarely took b supplements back then bt yes, high b6 can be caused by a buildup up of folic acid since it's the synthetic form and if u have the MTHFR gene it will build up and be harder to remove. That's why its important we always take folate instead of folic acid as I just found out. No doc has ever told me this ! I just read about it with the MTHFR gene. I just ordered b6 real folate (not synthetic folic acid) from Pink Stork (they had 5 star ratings)

folate is b9, not b6