Peptides for Lyme Disease and co-infections

Hi dcd, running wild, bailey and dude 🙂

Thank you all so much for the encouragement, that means a lot to me!

dcd: Hi yes you're so right about the mitochondrial health. I chose this one in particular because fatigue is my primary Lyme/Bartonella symptom. I wasn’t sure, for a while, which one to pick but several things made me pull the trigger.

One of those was ChickNorris her review about how it turned her fatigue around. Additionally, Dr. MR has an article on his website about how to address fatigue by addressing mitochondrial function. Although he doesn’t mention MOTS-c, it did help me understand mitochondrial function might be something I need to address.

This morning I did 2 mg (this actually was supposed to be between 5 or 10 mg but it went a bit wrong and I figured its best to be safe the first injection.

However, later on in the day I still hadn’t noticed anything, which wasn’t surprising because 2 mg is relatively low. So about 15 minutes ago I did my second shot, which was 12 mg. Which is 2 mg over target but it’s really hard to measure.

In total, today I did 14 mg and will now wait for a week to see how I feel. I just finished 15 minutes ago with my second shot so I’m still waiting to see what happens.

running wild: Yes it’s so sad these things are being banned. I will keep you posted

Bailey: I second everything dcd just said. He’s the guy to ask and yes the anhedonia is also something I read about. So yes, go slow.

Dude: Thank you haha I love the pun!

Will keep you all posted!

Rainy, did you read Robert Naviaux’s paper on mitochondria and the cell defense state? It’s one of the reason we tried pemf which was successful in many ways by terrible for vision which is why we’ve currently not been going full speed.

Best wishes on the peptide trial!

DCD, thanks for the advice! I promise to start slow. I always do. I did try to look around the internet and particularly Reddit. Reddit apparently kept labeling it as mature content after about 10 seconds of reading and would kick me off claiming I needed to make an account. Being contrary I just kept reloading the page and trying to read more in 10 seconds. Anyways, yeah most I saw someone here say they thought it caused a herx, and someone say it acted like a stimulant. I still haven’t decided what I’m trying tomorrow. We’ll see.

Thank you Garzie and Bailey for the best wishes 🙂

It's a few hours later and I'm still alive haha, will keep monitoring how I feel over the next week.

dcd: 🙂 Thank you so much for posting this! Please don't ever feel like you need to debate posting something like that. Whether it's good or bad, it's all welcome.

In regards to the warning, that's really good to know! I do have hair loss over my body but "fortunately" this mostly happened before TA-1.

I do have a new bald spot on my leg (post TA-1) that I should mention though.

If there's a connection I'm not sure in my case because of the prior hairloss, but certainly possible. I posted a picture a few days ago in the 'Gritty Bumps' thread. Some additional information: My last injection of TA-1 was I think late summer. I'm writing this comment in January and the new spot happened 1 or 2 weeks ago. I have no idea what the life cycle of hair is, so I can't comment on whether this means anything (in my case that is).

Thank you again and please don't ever hesitate to post warnings. I did the same about LL-37.

So you guys are better researchers than me so please correct me if I’m wrong. Honestly my brain is too much fo a mess right now to track down papers. I’m seeing posts that seem to imply bpc 157 may help favor the gaba side of the gaba glutamate balance.

Also I know these aren’t papers but found this phoenixrising post
https://forums.phoenixrising.me/threads/bpc-157.76399/

I want to try the oral KPV, but it’s out of stock.

Thank you Bailey!

WbF: that sounds like a great peptide. It says here that it's orally active, so that would be interesting to hear how it goes. I hope it's in stock soon. Seems like it's just one company selling it.

Hi Bailey!

I'm so happy to hear that you didn't have any extreme reactions and I think it's good that you keep an eye on your BP. I imagine it must be rough to start new things when you have strong reactions, so the fact that you tried it is a positive too!

My peptide trial is going ok. I have been timing intervals of when fatigue gets to the point of needing sleep.

So far I had 2 moments where I normally need to sleep but didn't. One of which was 2-3 hours.

The reason I said "ok" though is because it's still a bit early to tell, so I'm just being careful with being optimistic.

Thank you for asking 🙂

thanks for the update Rainy

hopefully more pronounced sleep and more activity when active are both actually movements in the right direction - at least as opposed to awake but feeling like death when awake, and asleep but restless and unrefreshed - as is often the case with this thing

Hi guys,

Just putting my MOTS-c schedule so far here:

January 19, 2022: 2 mg
January 19, 2022: 6 mg (second shot that day)
January 22, 2022: 9 mg
January 27, 2022: 9 mg

I initially thought the second shot on January 19 was 12 mg but, just like the first shot that day, something went wrong.

So as mentioned above, today I did 9 mg again. Actually just 10 minutes ago.

So far I'm impressed. I like how Garzie pointed out in his last comment how to more positively view the results.

Ever since my last update, the results have thankfully remained, but even more pronounced, so sleeping more, but also even longer stretches of being active. 😀

I'm very grateful for that. Maybe in time the sleep will decrease.... and maybe my body is seeing this as a chance to actually get sleep that isn't worthless, hence an initial increase in amount of hours, if that makes sense.

Also just for reference, the other things I'm currently taking are: Bactrim, Ceftin and Lumbrokinase which are often making me herx (aching/pain etc.)

good to hear Rainy!!

i know the feeling of never feeling that suffering will end - at such times even a brief glimpse of how thing can be better is a huge lift and provides hope.

Hope is a vital ingredient for human life

just a word to the wise - try not to do anything rash in your exuberance
its entirely natural to want more of the same when you have had a little taste
but after so long in the dark it can prompt us to do high risk things
like doubling doses of a powerful drug/herb, overdoing it physically and setting ourselves back
i have done it myself

i would just say try to keep everything systematic and rational - stick to the plan - and before making changes - think twice / act once

wishing you continued positive progress !!!

Thank you Garzie and Bailey!

Haha Garzie that's funny you pointed that out because that's actually where I was heading with the "makes me feel good so maybe I should try more" idea.

It's good for me to hear that. I'm going to stick to the plan more. Thank you!

Thank you Garzie, yes it totally makes sense and I appreciate you pointing that out.

After your comment I've actually spent some time trying to put together a MOTS-c schedule based on several sources. Which I am then going to stick to 🙂.

Will post the MOTS-c schedule here when I've figured it out!

Thank you Garzie, your help and encouragement is very much appreciated.

I finished my MOTS-c schedule. The reason I made the schedule this soon after my last comment is because I've already started the MOTS-c as of January 19th. So I don't want to lose the momentum. Granted, I did not rush the schedule and took a lot of things into consideration.

So this will be my schedule:

Monday - 7 mg
Wednesday - 7 mg
Friday - 7 mg

This schedule I will repeat weekly during my Lyme and Bartonella treatment. I might decide to take a break after a couple or few months, but I haven't decided on that yet. Granted, I still have a while to think about that as it doesn't apply as of right now.

I've taken lot's of things into consideration. Both studies and people's experiences that I've found online.

Scary fact: on some other forums (not this one) some people go overboard with a lot higher doses than I mentioned above in my schedule. Which, in my opinion, is unnecessary. Although it was nice to see that they didn't have any bad side effects even at those very high doses.

So all of that said, here were the sources I've used:

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Source #1 : Taylor made compounding (see their catalog on the first page of this thread) wrote this schedule: Suggested dosage: Inject 10mg subcutaneously weekly into the abdomen.

I felt that was on the lower side, due to what I've noticed myself and other reports also. I have to keep in mind that I have Lyme + Bartonella and therefore have a big issue, as opposed to other people who might take it for less serious issues than Lyme. Also the once a week thing didn't feel right, which leads me to the next source...
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Source #2 : Dr. William Seeds wrote in his book Peptide Protocols, Volume 1 the following: 5 mg of MOTS-C injected subcutaneously 3 times per week on a Monday-Wednesday-Friday schedule for 4-6 weeks, followed by a once-a-week dose of 5 mg for 4 weeks.

This seemed more reasonable to me, and I'll be using the W-M-F schedule that's mentioned here. However, the 5 mg still didn't sit right with me.
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Source #3 : From this study: https://www.nature.com/articles/s41467-020-20790-0

"We fed young mice (CD-1) a HFD (60% calories from fat) and treated them with 2 doses of MOTS-c (5 and 15 mg/kg/day; IP; Supplementary Fig. 3a)."

So this in my opinion is WAY too high (5-15 mg per KG per day) 😳. Also, I'm not a mouse haha and I wouldn't be able to afford this regardless. But even if I could afford it, I've read many people having benefits from a LOT lower doses, so this is not needed regardless of the money.

I think this study is actually part of the reason why some people use extreme doses. But people might forget that some studies use high doses so the result are easier to observe and don't always translate to human clinical doses.
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Source #4 : So this is not really a source but just from the experiences that I read online. Which is simply that some people prefer higher doses and some lower. I would link the reviews here if I remembered where I had read all of them scattered over the internet. So this is just from my memory and should be taken with a grain of salt.
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So those are the 4 sources I took into consideration.

In short: I won't be mega-dosing, but I am going to take a bit more than the first 2 sources, due to my severe fatigue caused by Lyme and Bartonella.

ps. I took my Monday dose just now.