Malarone and Rifabutin interaction

My doctor prescribed me malarone for Babesia even though I never tested positive for it. I am also on rifabuitn and azithromycin. My doctor never mentioned an interaction between malarone and rifabutin. However, I looked at the drug interactions and it said that there is an interaction and usage together is not recommended. Has anyone taken malarone with rifabutin? or is it safe to take these together?

So should I start it? Would it even be effective if its effectiveness is being decreased?

the rifampicin class of drugs have the same moderate interaction with pretty much all prescription drugs

if you read about the mechanism its due to the fact that they upregulate the liver pathway that most drugs are metabolised by - and so it causes most drugs to be cleared somewhat more quickly from the system

this does not stop the drugs from working at all - it is more just a moderate potential for interaction that prescribers should be aware of - and for instance does not stop all LLMDs who use Rifampicin's from prescribing other drugs alongside in combinations ( they are almost never used as single drug regimenes as teh research clearly points to poor outcomes for that approach).

Girlie said...
“ and for instance does not stop all LLMDs who use Rifampicin's from prescribing other drugs alongside in combinations ( they are almost never used as single drug regimenes as teh research clearly points to poor outcomes for that approach).“

Generally speaking - you don’t often see Mepron with Rifabutin taken together tho.

true enough - but i think that may be mainly because llmds are more often treating babesia and lyme
with say mepron and a macrolide - or bartonella and lyme - with rifampicin and a macrolide or tetracycline
rarely treating Babesia and bart together in the absence of lyme

or put another way - the same drug interaction as mentioned also applies to macrolides with mepron / malarone - but that is how they are recommended to be used for babesia.