Anyone been tested for nagalase?

that's a new one on me Bailey

i read a lot of mixed messages relating to it

it seems like a long list of things can cause it to be raised - so its not necessarily very specific - and the claims around treating it directly seem to all come from one guy

what are your extreme vitamin D issues ?

Anyone remember the Marshall Protocol?
(Lowering vit d levels - dark glasses outside etc)

Bailey said...
So my levels are low which is why all docs keeps telling me to take more. When I do I can become so inflamed I’m catatonic. Being in the sun is probably the only way I get d and don’t have issues

so that might fit with Marshall's hypothesis - although mainly he maintains that bacteria make stuff that blocks the vitamin D receptors - so that taking more vitamin D doesn't make any difference - as the receptors are already occupied.

but i think there is some suggestion that bacteria might also act through epigenetic means to reduce the expression of VDR in human cells - rather than block the VRD themselves - so if that's the case and you are low in vitamin D - adding more vit D might cause a sudden immune activation

but vitamin D is known to be needed by immune cells to function - so it may just be with v low levels your body is unable to mount a proper immune defence - then when you get some supplemental vitamin d - it suddenly switches on immune activity and you get her like reactions.

i wonder why sun exposure is not causing the same thing - but its actually quite hard to get enough vitamin D by sun exposure - so maybe that's why that's not triggering the same reaction?

as you already know low vitamin D is a risk factor for various adverse health conditions - so i wonder if its worth try starting supplementing v low and slow - to avoid a sudden immune activation type event.

many supplements are 3000iu to 10,000iu - but you could start with just 200iu of Vitamin D3 or something low like that - and then build up over time.

the other option might be to test both forms of vitamin d - the storage form and the active form - which might tell you if Marshalls work seems to apply to your case and if its worth doing down that particular rabbit hole

Bailey said...
Yeah even a tiny bit like multivitamin with 60 is mixed in water and dabbed on my skin gives me crazy immune activation

but what makes you think its the vitamin D that's doing it - rather than anything else in the multi?

after all there are often 40+ ingredients in a typical multivitamin

i only ask as many people on these forums have crazy unpredictable chemical sensitivities - or MCAS reactions - or just symptom flares triggered by all sorts of things even in tiny amounts - particularly those with bartonella in the picture it seems

some flare dramatically from just a single empty vegetarian type capsule on its own - not even anything inside - others flare from even the most supposedly anti-inflammatory herbs or supplements ...

the other thing that points towards it being something other than vitamin D is that sunlight doesn't seem to trigger it - 20mins in strong sun will start to make significant amounts of vitamin D - and if you are so sensitive the a little multivitamin dabbed on your skin would trigger a reaction - then i would expect sunshine to do it too - if not more so ....

just some thought that might help get to the bottom of it

could be - and i am not saying it isn't - just worth considering the alternatives when not everything fits

if it is vitamin D itself - there would need to be an explanation why sunshine doesn't cause strong reactions -

vitamin D3 is never supplied in pure form - its too strong - so could it be an excipient/filler/lubricant ?