ARA-290 for neuro-inflammation

Frustration maxing out here.

As people know I have severe neuropathy. Diet was helping, but it has gone ballistic for the past 3m after taking plaquenil and antimicrobials.

Well I was reading on Reddit and I came across a post by a man who was claiming to be making miraculous results with ARA-290 for his neurological symptoms. It's a small peptide being explored for neuro-inflammation and neuropathy. You can order it online "for research purposes".

Well last week after reading this post I remembered my experiment with it briefly in 2021 (see Note 2), and decided to give it a go again. I ordered it from Peptide Sciences and it arrived Friday. I went to Quest and got a baseline metabolic panel done Friday (see Note 1). I was in so much pain at the Quest Diagnostics I was literally shaking. I got home around 2pm and injected it into myself.

By 4pm that day the electricity in my feet had stopped. By the time I had gone to bed i felt significantly better.

I woke up yesterday feeling great. I could put my feet on the floor without wincing in pain. The pruning on the fingers was gone. No sweating dysfunction. At 9am I injected another 4mg.

I was ecstatic. This thing really f'ing works.

And then wham. The enthesitis started around 12pm yesterday. Quite badly. Been forced to take prednisone bendaryl and nasalcrom and its still there. I get some sort of MCAS or inflammatory reaction which I've been detailing on HW, and it ONLY happens when I take certain supplements. It appears that ARA is one of the triggers.

This is like some sort of cruel joke. I want to put my fist through a window. I'm so aggravated right now. After all these years of trying things, to find something that really helps, and to not be able to use it is beyond frustration.

But I figured maybe others could benefit from this info. On top of being great for neuropathic pain, it is shown to significantly reduce blood glucose and cholestrol numbers. I've seen it speculated it may work in chronic fatigue as well, as it shares a lot of the same neuro-inflammation characteristics of SFN.

Note 1: In early 2021 I tried this same peptide for 8 or 9 days. I remember thinking at the time that it was really helping big time, and I may have posted on HW about it. But then I randomly noticed my creatinine had spiked to 1.35. Since it's a synthetic form of EPO, which can affect kidneys, I got nervous and stopped. I did find in the literature one other case of someone's creatinine rising on ARA. I planned to monitor this and that's why I got a baseline before I started.

Note 2: It's only day 3 today, and I've gotten excited about improvements before only to have it be placebo, or the thing stop working. But this feels different. My feet have been an electrical outlet for months, and it was gone in hours. I dont think it's placebo. I thought about waiting to make this post until I confirm it is what I think it is, but it looks like I may not be able to use it going forward, and wanted to get this off my chest.

Study on ARA for sarcoidosis induced SFN (sarcoidosis causes nerve root inflammation, but ARA seems to work for many types of inflammatory SFN):

https://www.youtube.com/watch?v=xggiey1zfm8

ARA for diabetes:

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4365069/

Interesting discussion on ARA by a practitioner using it:

https://us02web.zoom.us/rec/play/oywq67b08q9caikkn33epyckqxic96-utgj2rrccft2-0bwdqd85prxl6rv2-cmvbgxyoyavprrdn9ub.7b53si7uuli5t1lv

Post Edited (dcd2103) : 4/10/2022 10:21:37 AM (GMT-6)

RainyCloud said...
I'm so sorry to hear this dcd.
I don't really have anything to add besides feeling awful for you.
How frustrating this is....

What do you think caused it to come back with a vengeance?

I wonder if it made you able to move more and then when it wore off the pain from all the moving around set in.

Just a random thought I had...

Hey rainy. Thank you for your concern my friend, it does help to know we've got a community here.

I dont know why I'm reacting this way to various supplements. But it's definitely inflammatory. I can feel the inflammation in my back and tendons. Many supplements have done it too. Vitamin D2, benfothiamine, allithiamine, tudca, alpha lipoic acid.

No clue why. It definitely responds to nsaids and steroids. I did think that it was responding to benadryl at one point. I'm trying to confirm that today. If it does that would mean it's more of a histamine response.

I almost wonder if I have mold triggering my immune system and creating this sensitivity to supplements. Almost feels like multiple chemical sensitivies-ish. I went to an immunologist the other day who confirmed w/ allergy panel that i have a mold allergy. My back swelled up pretty good around the mold contact points. Maybe this is MCAS, but I've never seen someone report tendon pain from MCAS, and I dont really have any of the other symptoms. The immunologist gave me a 24hr urine test to look for it. She also gave me itraconozole for the mold/fungus. Dunno if I'll be able to handle it.

Rainy fyi I spoke w/ a woman who is in a group. about 100 or so members, using ARA for various neuroimmune diseases. She said that moderator is using it for CFS, and has been on it for a year w/ amazing results. Unfortunately the word is that once you stop the neuroinflammation comes back, but apparently its working well for CFS for a lot of people in the group.

As mentioned it works quickly, within hours, I'd be curious since you are into peptides and suffer from CFS, if it helped you.

She spoke w/ the CEO of Araim pharma, the company which was researching this. Apparently they completed the trial w/ amazing results, but just could not secure funding. This is similar to what i heard directly from the mouth of a ceo at another company researching a drug for neuropathy. Private equity just does not see this as a profitable enough area to invest capital in. They all want the next cancer or MG drug, diseases where treatments sell for $200k/year

Post Edited (dcd2103) : 4/14/2022 10:23:44 AM (GMT-6)