newuser22 said...
I did about three months of dapsone, 100 to 200mg/day.
During dapsone and even after stopping dapsone I had crazy fatigue.
I did blood test last week.
I know I have iron issues from my history of last few years.
I also have metabolic syndrome. Very high cholesterol levels and insulin resistance. Very weak, irritated, shaky, unbearable on fasting, cognitive problems even after meals. I am a lean person with good healthy diet.
Metabolic syndrome is caused by Lyme.
I took liquid iron, and my condition improved.
I took chromium supplement, my insulin function is improved.
Thinking what other minerals micro nutrients does, Lyme/dapsone/abx deplete.
a large proportion of the population of the western world are iron deficient - its one of those deficiencies that seems to get cause in a feedback loop and is hard to correct once low
but dapsone is also well known to drive anaemia - which will cause dramatic fatigue
and often makes people feel v ill - as its well known to be a hard drug to tolerate for most lymies - normally only with close drs supervision and safety labs each 2 weeks initially
- liver funct tests
- CBC
- some measure of haemoglobin oxidation / methemoglobinemia
- maybe folate levels
200mg per day is double the standard dose
v high doses of folate in multiple forms are normally needed to be taken along side it to avoid the worst of the anaemia - did you do this? ref Horowitz and his dapsone protocols in the book - How can i Get better
were you tested for methemoglobinemia while on it ?
if you are iron deficient then obviously adding iron in some form is likely to help - but it doesn't necessarily mean this was the main mechanism by which Dapsone was making you feel so ill
(obviously - it will not have helped and it makes sense to correct it)
generally animal sources of haem iron - like liver and blood - are much better absorbed than ionic / mineral forms of iron - i think vitamin C and other nutrients are required for its proper absorption also - so may be worth checking that out.