thanks Vimzor!
i was not aware of that company -
i have however done a good deal of microbiome pcr testing and delved into that site and had some correspondence with the guy that runs it.
overall there are problems with his approach.
firstly - the PCR labs themselves do not agree with each other as to what is in the same sample
and i am not talking about
small degrees of difference - but utterly opposite results at even the phylum level
this cannot be right / or accounted for by differences in databases - something is fundamentally wrong with some of them - or all of them - and we as users have no way of knowing which if any are good
so there are issues with the base data the website is trying to use to draw conclusions from and therefore to drive interventions from
secondly - i think the fundamental premise is barking up the wrong tree
the guys main theory is that chronically ill people with gut symptoms are being made ill by "a 1000 tiny cuts" of many different bacterial species being overgrown or under grown and this is the root cause of their problem - thus adjusting the microbiome back to what is regarded as normal will cure their symptoms
here more problems arise
the definition of normal is very much unclear - there is no one normal template for a normal microbiome - you can find apparently healthy people with a wide variety of microbiome patterns - so what is normal for any given person is so far unclear - and given the issues with the technologies/ companies measuring them also being unrepeatable from one to the next - this remains problematic.
but perhaps the largest problem is with the basic underlying premise itself
people who are chronically ill with say lyme and or bart typically do not get much colonisation of their gut by the so called beneficial bacteria when they supplement with them.
research shows that inflammation in the gut changes this microenvironment in ways that makes it less hospitable to these more fragile and fussy bacteria and towards more pathogenic ones and that this may be a more likely root cause for changes in the microbiota associated with these illnesses.
thus a more suitable premise may be that the gut is inflamed due to infection with an intracellular pathogen in the cells that line the gut changing its ability to support a beneficial mix of gut bacteria - and this is the root cause of the changes in the gut microbiota seem in chronic lyme / bart etc al patients
in this case changing foods that feed certain bacteria that are seen as lacking in the microbiome or introducing probiotics to try to supplement those that are seen as missing, may do little to impact the overall system. flowers will not grow in a garden that is too dry - or too wet - no matter how many you plant or what fertilizer you put down.
this has been my experience also - after 12 months of eating probiotic foods loaded with more live bacteria than you can get from supplements my levels were still barely registering on PCR stool tests - and my overall gut symptoms were more or less unchanged .
these are of course just my observations thoughts - but i have looked into it in some depth and tried many things along these lines.
Post Edited (Garzie) : 7/24/2022 6:13:26 AM (GMT-7)