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Sida Acuta is bad for you???

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Posted 1/11/2023 4:07 PM (GMT 0)
I just came across this scientific experiment where Sida Acuta caused anemia, blood cell count drop, and other problems in rats...

https://www.researchgate.net/publication/326129522_ALTERATION_OF_HAEMATOLOGICAL_INDICES_ON_ADMINISTRATION_OF_ETHANOL_LEAF_AND_ROOT_EXTRACTS_OF_SIDA_ACUTA_IN_ALBINO_WISTAR_RATS

I don't get it...
Posted 1/11/2023 5:47 PM (GMT 0)
2 things to bear in mind when interpreting this type of animal based trials:

1, humans are not rats - many things that are toxic to animals are not to humans - for example cannabis and chocolate are both toxic to dogs - but not to humans.

2, dose - if you read that study, the measures they gave for the doses were dried extracts of the plant.
These equate to 10 to 20x the doses in tincture form that humans usually use.

if you gave 10-20x the dose of many medications to humans - you would measure anomalies in blood counts etc
Posted 1/11/2023 6:27 PM (GMT 0)

Garzie said...
2 things to bear in mind when interpreting this type of animal based trials:

1, humans are not rats - many things that are toxic to animals are not to humans - for example cannabis and chocolate are both toxic to dogs - but not to humans.

2, dose - if you read that study, the measures they gave for the doses were dried extracts of the plant.
These equate to 10 to 20x the doses in tincture form that humans usually use.

if you gave 10-20x the dose of many medications to humans - you would measure anomalies in blood counts etc

This ^
Posted 1/11/2023 7:23 PM (GMT 0)

TheRhythm said...
I just came across this scientific experiment where Sida Acuta caused anemia, blood cell count drop, and other problems in rats...

https://www.researchgate.net/publication/326129522_ALTERATION_OF_HAEMATOLOGICAL_INDICES_ON_ADMINISTRATION_OF_ETHANOL_LEAF_AND_ROOT_EXTRACTS_OF_SIDA_ACUTA_IN_ALBINO_WISTAR_RATS

I don't get it...

It's not only with rats or animals. I think the same can go for humans. We just never know. All I know is sida acts as a stimulant. I couldn't tolerate it because of that. I wish I could, because ai believe sida is one of the most useful herbs and would have been the key to my treatment, it would have been beneficial to me, what a bummer.
Posted 1/11/2023 8:05 PM (GMT 0)
i take 40 drops 4x a day and have for over a year -

i experience no stimulant effects at all from it - i take it before bed and sleep better now than before i started it

medicalnerd - its clear you have a strong individual reaction to the herb. Not doubting that. from your other posts its also clear that you have strong reactions to many herbs, supplements or medications.

this being the case i would not assume sida is a stimulant per se - just that you have an unusual individual reaction to it - which is not so surprising in someone who is sensitive to many things.

in other animal trials it actually demonstrated to have sedative effects

it could be that the reaction you experienced is a kind of herx reaction - causing rapid heart beats etc - i have had herx reactions like that myself
Posted 1/11/2023 9:38 PM (GMT 0)
Sida acuta and cryptolepis contain cryptolepine. I had trouble tolerating it. It caused fatigue and nervousness similar to anti-folates.
Posted 1/12/2023 5:58 AM (GMT 0)
I have never understood the justification for not taking a study seriously solely because people aren't rats. That entirely invalidates the purpose of animal testing in the first place. Seeing that this study is not a first of its kind, it should be given importance.

Comparing who sida provides a stimulant effect for and for whom it does not is meaningless because everyone is unique.
Posted 1/12/2023 1:19 PM (GMT 0)

LabRatDeluxe said...
I have never understood the justification for not taking a study seriously solely because people aren't rats. That entirely invalidates the purpose of animal testing in the first place. Seeing that this study is not a first of its kind, it should be given importance.

for clarification - i think there is a misunderstanding here

interpretation of medical trials is a complex and nuanced business

no one is suggesting that animal trials that show adverse effects are disregarded

simply that we cannot safely assume an effect seen in one trial on animals when given at 10-20x human doses will occur in humans

does that mean we should not be concerned at all? - no - of course not.

just like a trial in rats that showed a drug had no harmful effects to the rats does not immediately qualify it as safe to humans.

it just means that we might need to look at the wider picture of all the research on the topic, in vitro studies, animal studies, human trials, clinical use etc and form a balanced opinion.
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