Disulfiram is the single most effective thing I have done once I had been sick for a few years other than the initial doxy treatment (which worked quite well but I got worse over time even with more courses of doxy)
I do mean mean literally the SINGLE best thing. I did Disulfiram as a monotherapy and it outperformed complex combo abx/herbal treatments that I had done previously.
I started quickly after Dr. Liegner's case report studies came out. Not knowing any better, my doctor and I had me start at 500mg a day. The herxing was extreme. I had to stop and start several times over the course of 3-4 months. After those 3-4 months I realized that I had slowly made great improvements. I was able to do things that seemed incomprehensible to me just a few months earlier. Was able to get out the house way more without crashing/relapse. Started a semi-consistent gym routine (I was actually able to get to the gym). For Xmas that year I was able to travel to my mother-in-laws and stay for 5 days without crashing or feeling too bad (I had to get a week memebership at a local gym to move my blood and stick my diet but everything went well). Unfortunatley, after a few months I came off of DSF and everything slid backwards over time to where I was right back where I began.
The potential side effects are WORSE than most treatment interventions. That is why great care must be taken. Labs to be performed regularly, psychiatric symptoms possible, nerve damage possible, there was a case report recently of a person that died while using DSF as a part of a larger Lyme protocol.
https://www.mayoclinicproceedings.org/article/S0025-6196(21)00408-0/fulltext
Important note from the article: "Per his wife, he took his medications at higher doses than prescribed."
Most likely you aren't going to die, however, if the herx/side effects are starting to feel severe it's smart to stop treatment to recover IMO. Additionally, you can't ingest alcohol and, in my experience, once you start to get to higher doses you have to be careful with diet. Coffee made me feel weird. I would feel randomly weird after eating at times. Based on my own patterns it felt like it was smart not to have carb heavy meals.
FWIW, I asked my current doctor, a well-known doc in the Lyme world, what he thought about
DSF. He said it was a "flash in the pan" and he understands people are desperate. I have to disagree with that somewhat based on my own experience. I've been sick for so long when something works it is easy to notice as it changes the day to day misery.
All in all I'm torn. It worked pretty good for me (not remission) and gave me some light in my life that I haven't had much of. On the other hand, it's a tough drug to tolerate and potentially dangerous. I would try to make advances with other methods first.
Post Edited (Lymie24) : 1/23/2023 9:15:33 AM (GMT-8)