Posted 2/4/2023 7:25 PM (GMT 0)
sure - i follow what you are asking
but no, as far as we know the higher numbers is not related to higher numbers of bacteria
the tests listed are all serological in nature
this means they do not look for or test the actual presence of bacteria themselves - but instead they use the activity of a persons immune system towards proteins found in the bacteria as a surrogate measure for infection. They do this by measuring the amount of antibodies to the pathogen that a person is producing or the reaction of white blood cells to the pathogen
its called an indirect test method - most infectious disease testing is done like this.
its cheap and quick and works well for most simple infections ( but unfortunately not so well for lyme and co-infections)
unfortunately in chronic infections the amount of antibodies or immune reaction a person produces is not really dependent on how much bacteria are in them - more to do with how the immune system is behaving - which differs from person to person.
low positive or indeterminate results are pretty common in people here who have been ill for some time.
in any case, Armin labs sets the positive thresholds where they have for a reason - weak positive is still a positive, if that makes sense.
the CD 57+ test can be another possible way to help support a Lyme diagnosis - as its often suppressed in lyme patients - but there are other unrelated conditions where its suppressed - and in some lyme patients its actually elevated - so its not a particularly specific test for lyme.
where it can be useful - is in people with lyme - if its v low initially - there is some evidence that it can be used to track recovery as it tends to recover as they recover(there are currently no tests that can show Lyme is no longer present -- so that's why there is some interest in this test for that purpose).