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Interesting paper on Toxoplasma Gondii

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Posted 11/7/2023 5:56 PM (GMT 0)
this little beast crops up quite frequently in the medical research literature

its claims to fame are that it
- is known to cause rodent to show interest in, rather than fear of, their main predators - cats
- is disproportionately present in self made millionaires
- is associated with risk taking behaviours in humans
- as well as increased risk of psychiatric issues and risk of suicide (so not all good)

this latest paper indicates it may be playing a role in the accelerated frailty and muscle mass loss (sarcopenia ) in elderly humans

infection with this pathogen is known to be very common in human populations - being easily contracted from cats litter trays - cats themselves - undercooked meat - or even from vegetables from contaminated soil

the authors found a surprising 67% seropositive rate in the elderly population they studied - and higher titres were associated with worse outcomes in physical and mental decline.

i mention it here as some LLMD's believe its part of the Lyme Borreliosis complex of borrelia and co-infections.
This makes a certain amount of sense as its known to be another of these infections that is typically dormant and under the control of the immune system shortly after initial infection - but things that suppress the immune system can cause it to reactivate.

i think i remember Dr J saying that its one of the reasons he likes to use daraprim in his persister protocol

abstract said...
In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant.

paper here
https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glad228/7334598
Posted 11/7/2023 6:22 PM (GMT 0)
I was tested some years back and was surprised that I was negative. I had cats for years and was the primary litter box cleaner. I never used gloves or a mask. My cats were indoor/outdoor and got fleas and ticks.
Posted 11/7/2023 6:23 PM (GMT 0)
What’s the effective treatment for toxo?
Posted 11/7/2023 7:18 PM (GMT 0)
I’m repeating what I have posted before - I have often wondered if I had Bart as a child.
Many cats and cat bites and scratches.
I think I was keeping it at “bay” for the most part except for a few anomalies - such as chronic diarrhea and the whites of my eyes had a yellow tinge (jaundice?)

And then several years ago I went through a tough time - I was working full time at a stressful/busy job and most evenings I would go to the elderly care home to see my father - then I would go home and do paperwork for an hour or two before going to bed and do it all over the next day.

Maybe being run down allowed the disease to take ground…
Posted 11/7/2023 7:31 PM (GMT 0)
I suspect toxoplasmosis cannot be eradicated, just put into remission.

The paper below lists 50 common treatments and their relative rankings.

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro
https://pubs.acs.org/doi/abs/10.1021/acsinfecdis.8b00113
Posted 11/7/2023 7:59 PM (GMT 0)
thanks Carl

i will take a look

toxo is one of those parasites with some very clever tricks up its sleeve - aside from its ability to chemically influence the behaviour of its host in ways that favour its transmission

it is known to coat itself with host proteins in the muscle and brain tissue - and live inside these layers of host tissue long term in an encysted state, completely invisible to the hosts immune system - but while still having chemical effects on the host.

it reminds me a little of Babesia in that respect - that its known to sequester in the circulatory system in what appears to be a similar low metabolic state - and is also apparently somehow also evading the immune system is some way while its doing this.

it seems these apicomplexans are way more complex with more tools in their toolbox that the average bacteria
Posted 11/7/2023 8:51 PM (GMT 0)

carlnpa said...
I suspect toxoplasmosis cannot be eradicated, just put into remission.

The paper below lists 50 common treatments and their relative rankings.

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro
https://pubs.acs.org/doi/abs/10.1021/acsinfecdis.8b00113

Here's more of the paper, but it's not the final, edited version.
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6093624
Posted 11/10/2023 7:34 PM (GMT 0)

The Dude Abides said...

Here's more of the paper, but it's not the final, edited version.
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6093624

thanks Dude!
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