just noticed this article on Lymedisease.org with an update on Hygromycin A - from February this year
https://www.lymedisease.org/hygromycin-lyme-drug-trials/for those that haven't followed the topic - its an antibiotic that is highly specific for spirochetes - discovered decades ago but never developed further because of lack of commercial case.
that much is good - but the rediscoverer of it - the distinguished Prof Kim Lewis is on record as saying he doesn't expect it to be effective for chronic lyme - rather that it is expected to be useful for initial / acute infections
his specialist field is persister cells and biofilms etc so i think it likely that he said this as he knows many drugs are effective for acute infections - but not against chronic ones or persister cells and their associated biofilms ( chronic infection, persister cells and biofilms are all associated phenomenon)
however - the story seems to have changed a little - and he is now being funded by the excellent Cohen foundation to do human trials for Lyme - again i think still targeting acute infections - but i think it will inevitably be tried for chronic lyme at some point also. That s after all where the larger problem is.
they are targeting phase 1 human trails - this year -
(this is where the test if its safe for healthy people)
phase 2 would be expected to follow a year or so later if phase 1 went well -
(this is where they test different doses for efficacy on around 200 people who actually have lyme)
the only other thing to note is that Lewis seems to be suggesting that Chronic Lyme was caused by a disturbance or the microbiome - and he uses this claim to reason that Hygromycin A will have an advantage over current abx - as its narrow action should leave the human gut microbiome largely unchanged - thereby causing less "chronic Lyme" after initial acute treatment....
while it will be good to have new antibiotics in the lyme toolkit - i think that is a highly dubious claim - and a rather odd thing to say for such an educated man.
(after all - many of us have become sick with chronic Lyme without taking antibiotics for acute lyme - because acute lyme was never diagnosed - so it was never treated until much later - so this claim seems patently false)
lastly - i think i saw a facebook group where patients were having a batch made for self medication - despite the lack of human safety date - but i dont know the outcome of their trials or of there is any organised / rigorous data collection going on there