LDN + daily thyroid med and occational alcohol use? Tell me what you know.

the original use of Naltrexone was to block the euphoric effects of alcohol - by blocking opiate receptors in the hope that people would get less reward for their habitual use disorder and the addiction/reward cycle would then more easily be broken

but the starting dose you mention is 1/100th of the standard dose of naltrexone for that purpose
so i doubt you will have ill effects from using it alongside moderate alcohol - though the beneficial effects of LDN could be interrupted as alcohol acts on the reward system - which is also what LDN acts on.
LDN to blocks endogenous opiates - alcohol stimulates them - so you can see the potential conflict

for what its worth - the LDN research trust believes it works in auto-immune disease by reducing self directed white blood cell activity / normalising immune responses and thereby reducing auto-immune inflammation

it follows that, in theory, if it does cause peoples thyroid meds requirements to change, is by reducing auto-immune attack on the thyroid tissue and therefore allowing the gland to recover and thereby restoring more normal thyroid function

however logically - while I can see this effect happening if a person has only had AI thyroid disease for a short time and most of their thyroid gland is intact - i am not sure how much of this is likely if a person has had AI thyroid disease for decades - as one would reasonably expect the thyroid tissue to be damaged permanently.

happy to be proved wrong - just sharing what is thought to be the context and mechanism at work

i hope its of some help

In my experience with LDN and alcohol, the LDN may actually raise tolerance slightly.

No adverse reactions at all.

LDN dosing sounds like a reasonable plan - but be prepared to adjust depending on how you get on - some people are remarkably sensitive to it - and others not at all. once i was in the effective range for me - i had to increase in only 0.01mg increments to avoid sleep problems and pain all over during the ramp up phase

ref alcohol - since they have opposite actions on the opiate system ( the system by which LDN is believed to act on the immune system - alcohol increases endogenous opiates for a while - whereas LDN blocks or suppresses opiates for a while ) - there is a fair chance that the alcohol consumption on the the same day counteracts the LDN from doing anything useful .

Paper said...
said]Alcohol intake may alter, not only the activity of the endogenous opioid peptide system, but also the density or affinity of specific opioid receptors in distinct regions of the brain. Such changes would alter the interactions of the opioid receptors with their respective ligands and, as a result, would alter the functional activity of the whole system.

so i think if it were me - for the duration of the trail ( until i knew if LDN was helping me or not) - i would simply skip the alcohol - to get a clear answer one way or another
otherwise i would not know if LDN just wasn't going to work for me - or if it wasn't working because alcohol was countering the effects.

that said - the overall balance probably depends on how often a person consumes alcohol

For instance - if a person was to take LDN every day - but only take alcohol in moderation say once per week - then 6 days out of 7 is still the large majority - and should still be enough for LDN to do its thing - and cause the body to gradually increase endogenous opiates over time as is intended - so consuming alcohol at that level should not be much of an issue either way -

whereas consuming alcohol at say 3 or 4 times more or per week may mean most days LDN not doing as intended

timing may be important also - since both have short and long term effect on the opiate system
taking them at the same time of day may have more direct counteracting effects
taking them at opposite ends of the day may have less counteracting effects

however this is all logical mechanistic reasoning based on what is known about the mechanism of actions of both substances - and in practice not everything is known and it may not work that way for reasons that are not yet fully understood

a rather deep paper on the topic of alcohol and the neuro-endocrine system - including endogenous opiate system here
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc167184/