The density of Cryptolepis Sanguinolenta root powder and dosing information - tincture to powder

well done on measuring the density Rainy - i would do it the same way and get the same result

ref the calculation for how much herb is in the tincture

in fact tinctures are made with a weight for weight recipe - so you do not actually need the density for that part

100ml of 1:5 tincture was made with 100ml of solvent and 20g of herb - so contains roughly 100/6 of the herb = 20g
( although strictly speaking some of the solvent is left in the spent herb after pressing - and some of the active herb components remain in the spent herb too )

this is where trying to get an exact calculation of the equivalent dose for powdered herb and tincture gets a bit tricky

on the one hand - the herb in the tincture has been dissolved and is in a very finely divided and therefore more accessible form - but then tincturing will not extract all of the available active compounds.
exactly how much depends on solubility of each compound in the tincture medium - in this case alcohol and water ( which are generally pretty good solvents)

on the other hand - although a person may ingest a known amount of pure powdered herb - the human gut is also not 100% effective at extracting the compounds in the powdered herb ( as with most drugs only a portion of that is ingested is absorbed through the gut membrane ) - in fact it may be significantly worse than soaking the herb in alcohol for 1 month - and this efficiency of absorption differs for each active substance.

you can think of it as the relative effectiveness of bile and digestive juices vs alcohol and water as solvents.
some the active herbal substances are dissolved quite well in the bile juices - other things less so - but are more soluble in alcohol and water.

so, while it is still a useful reference point to calculate how much equivalent dry herb is in a tincture dose - in practice - the other variables of availability, solubility and absorption are typically large enough that they become the driving factor in most cases

unfortunately these are rarely researched in detail - and instead we have to rely on empirically established dosing guidelines for herbs in tincture form vs powder.

as examples- if we look at Buhner's recommended doses as a reference we can see that there is sometimes a roughly equivalent dose 1ml of tincture vs 1g of powdered herb - despite this in theory having only 1/5th of the herb in it - presumably because the tincture is much more effective at extracting and making available the active compounds than the human digestive juices. Japanese knotweed is one such example
where his suggested dose is 30ml of tincture or 30g of dry powdered herb

and at other times the tincture dose in ml is 3x the powdered herb dose

powders have some other advantages though - they are less work than tincturing - and require less equipment for instance - so Buhner was quite happy to recommend them.

anyway - sorry for the long winded explanation -

by way f something more helpful - i have just dug out Buhner's Herbal Antibiotics book - in it there is a section on Cryptolepis

under dosing it gives a suggested

tincture - 1:5 tincture 60% alcohol - 20-40drops 4x a day
( that is long term dosing - he does suggest doses of up to maximum 1tablepoon -15ml 3x daily for 60 days absolute maximum for severe drug resistant staph infections )

tea - 1 teaspoon of ground herb in 6 ounces of water ( i used it steeped overnight in acidified water as he suggests in the same book ) - take 1-2 cups a day as a preventative and up to 6 cups a day in acute ( short term) conditions

powder - 3x 00 size capsules twice a day as a preventative - and up to 20 capsules a day short term in acute conditions
( btw an 00 size capsule holds around 0.91ml - so using your density data - each holds 0.91*0.5375=0.49g
so 6x capsules is a daily dose of around 3g )

its interesting to compare this to his tincture dose of around 2-4ml / day is essentially the same as the powdered herb dose - but uses approx 1/5th of the dry herb

finally, i believe i read there is some long term toxicity concern - or at least a lack of long term data on cryptolepis which is i think the reasons for Buhner's caution around the very high doses long term

i hope its of some help !

in the 1:5 60ml example

the 1:5 is just a ratio - so the dry herb is always 1 part and the menstruum ( liquid) is 5 parts ( by weight )
so 10g of dry herb was used with around 50g of liquid - or some multiple of that
( we can ignore the losses and the millilitres to grams conversion here for simplicity - as we have already established - other factors have greater effect)

000 capsules - those are real horse pills! - well done getting those down!! 😀

oops - just noticed in the above example i wrote 60g of liquid when i should have written 50g - so i have edited that - apologies for any confusion caused