Hi Hilary,
I have a good friend who did the novantrone for 2 1/2 years and it worked wonders for her (she was able to come out of her wheelchair).(She took Avonex while on it) She is now on Tysabri and doing well. (But she has only had 3 treatments so far). I am seriously considering one or the other myself.
I hope you find the right combo for your hubby...keep us posted!