James, personally I have not been concerned, nor has my wife, with possible side effects. They are listed and we are aware of them, but given that all drugs have side effects and the benefit these particular ones give to a recovering ED/PCa patient, it isn't an issue. Penile pumps are ok, as far as it goes, but the pills affect the whole circulatory system in the abdomen and penis area, and gives a longer lasting effect, allowing for better blood flow and infusion of tissue that a pump alone can do. Most of us who take the pills here are taking them for therapeutic ed recovery, not for the primary purpose- the ability to have sex.
I suspect that if you switch to Trimix and get the dose adjusted by experimenting a little, you will be very satisfied with the results. Given the choice between the pills and the injections, I would take the pills every time, but I don't have that choice yet...