Doxycycline and other tetracyclines in the treatment of bone metastasis.

Folks, I have used doxycycline off and on for years.  Of course you can not use it on a regular basis; I use it about every 3 to 4 months for a weak or two at a time.
 
As some of you know I do the shotgun approach (my invention) to fighting cancer.  I will do about anything that might help, as long as I don't do my body harm.  Works for me.  Still psa under .01 after 16 years, gleason 9, in lymph nodes. Never had a rise in psa.  No brag, just thankful.
 
 
Will

P.  S.  Not intended for advice.  I hope I have not broken any rules by posting a research project from Pub Med.

Anticancer Drugs. 2003 Nov;14(10):773-8.

Doxycycline and other tetracyclines in the treatment of bone metastasis.
Saikali Z, Singh G.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Abstract
The tetracycline family includes tetracycline, doxycycline and minocycline, all of which have been used as antibiotics effectively for decades. New uses emerged for these compounds after their effect on mitochondrial function was discovered. Cytostatic and cytotoxic activity of these compounds was shown against cell lines of various tumor origins. In addition, tetracyclines and chemically modified tetracyclines inhibit the activity of several matrix metalloproteinases (MMPs). Given the importance of these enzymes in tumor cell invasion and metastatic ability, the potential use of tetracyclines in cancer therapy needed to be investigated. Col-3, a chemically modified tetracycline, is now the subject of clinical trials in cancer patients. However, the potential of tetracyclines in cancer therapy takes on an added dimension in the bone. MMPs have been shown to be important mediators of metastasis formation in the bone, contributing largely to the morbidity of breast cancer and prostate cancer patients. The natural osteotropism of tetracyclines would allow them to be highly effective in the inhibition of MMPs produced by osteoclasts or tumor cells in the bone. This hypothesis has now been confirmed by experimental evidence showing that doxycycline reduces tumor burden in a mouse model of breast cancer-derived osteolytic bone metastasis. This effect is likely due to a combination of multiple roles of doxycycline, including MMP inhibition and a negative effect on osteoclast differentiation and survival. These encouraging results have now paved the way for an ongoing trial of doxycycline in early combination therapy for breast cancer and prostate cancer patients.

PMID: 14597870 [PubMed - indexed for MEDLINE]


Publication Types, MeSH Terms, SubstancesPublication Types:
Research Support, Non-U.S. Gov't
Review
MeSH Terms:
Animals
Antibiotics, Antineoplastic/pharmacology
Antibiotics, Antineoplastic/therapeutic use
Bone Neoplasms/drug therapy*
Bone Neoplasms/secondary*
Breast Neoplasms/pathology
Cell Line, Tumor
Clinical Trials as Topic
Doxycycline/pharmacology
Doxycycline/therapeutic use*
Female
Humans
Male
Matrix Metalloproteinases/antagonists & inhibitors
Prostatic Neoplasms/pathology
Tetracyclines/pharmacology
Tetracyclines/therapeutic use*
Substances:
Antibiotics, Antineoplastic
Tetracyclines
Doxycycline
Matrix Metalloproteinases
LinkOut - more resourcesFull Text Sources:
Lippincott Williams & Wilkins
Ovid Technologies, Inc.
Swets Information Services
Medical:
Bone Cancer - MedlinePlus Health Information
Molecular Biology Databases:
DOXYCYCLINE - HSDB
Supplemental Content
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Interesting. I have taken tetracycline regularly for years (20+), and was found with a Gleason 4+5 post-DaVinci.

Did it do nothing, or should I have been dead years ago?

Will:
I recall that you had adjuvant orchiectomy all those years ago, which would certainly have been the ne plus ultra of your treatments.

I am posting on behalf of a friend who had prostate cancer (had prostate removed) has been doing the raw food diet etc. but now has bone cancer pretty widespread ( skull etc.) . I read about the Dr. at McMaster U. in 2003 ? and wondered what the outcome of his trial on Tetracycline was ? My friend is willing to do anything ( is juicing etc.) . Is this old drug taken orally or by injection? and where can you get it? Would it have to be prescribed here in Ontario Canada? (If so good luck finding a Dr. who will sign a prescription for it for bone cancer. Possibly my buddy could eat a bunch of chocolate and get acne then get a prescription. (Not likely he is on morphine ) Any assistance or information on this would be greatly appreciated