From: DR. Mark Moyads book (Beyond Hormone Therapy) page 92 & 97 (Abiraterone & Tak-700) are comparative and both them differ some from Ketoconazole (even though they target the enzyme CYP17), Mark says hydrocortisone is not necessarily needed with these (but likely I guess suggested by many), but with Keto is usually given or needed. TAK-700 by Millennium and Takeda Co., phase III trials, may become FDA approved is my guess.
TAK-700 & Abby drug: 'adrenal androgen synthesis inhibitor', supposed to have less side effects than Keto drug, less need for steroid replacement therapy. Note this drug is also believed to work by not allowing the tumor itself to make male hormones (which at some juncture the cancer can do just that...produce its own), which is why this drug is also known as 'De novo androgen synthesis inhibitor. This drug can cause blood pressure increase (hypertension), low potassium levels and lower-limb swelling (edema), docs can prescribe other drugs to reduce side effects such as this. (do not use DHEA while on these drugs, it can ruin the efficacy). Just thought I would elaborate on this since, we will likely see more people using this or getting into trials with it. Hope it works well, looks encouraging.
Also, would yield to Ralph's very long term experiences in support groups and PCa issues, he literally has seen most everything and can elaborate on plenty with first hand knowledge (you don't get that from a book), so Ralph excuse my additional stuff on this.
Post Edited (zufus) : 7/13/2011 3:55:25 PM (GMT-6)