IMMUNOTHERAPY Club (Provenge/Prostvac)

I've seen a lot of guys recently posting that are just starting (or considering) Provenge.  I thought it might be beneficial to list the HW Provenge users..  I'm sure the new Provenge guys would be interested in what you found beneficial or not.  So...If you've had Provenge (or in the process of / or even considering it as an option) and don't mind listing your HW name...I'll update this first post with names and any other information that you might find important.  (Changed from the Provenge Club to the Immunotherapy  Club to include Prostvacers and not just Provengers.) Name Date Infused Comments / Concern Additional Information PROVENGE /   PROSTVAC adjust 1/7/14 Prostvac Trial started 1/7/14 www.cancerresearch.org/prostate-cancer www.onclive.com/publications/obtn/2013/may-2013/Beyond-Provenge-The-Next-Steps-With-Immunotherapy-in-Prostate-Cancer PROSTVAC     49packard 5/1/12 Completed Provenge: 6/1/12 PROVENGE Devasted1 March, 2010, third treatment in April, 2010.   4th treatment in July, 2010 (post RRP). Last recent PSA test came up with non-detectable. What a miracle, for a Gleason 9, stage 4 can be and is non-detectable after four years.  Randomly selected for the 4th treatment. PROVENGE JCRush How do you know Provenge is working? Last infusion: 1/20/14 PROVENGE         PROVENGE Kayak808 Trying to get HMO appoval; review board in Jan., 2014. Update:APPROVED...starting March, 2014; Finished infusions...4/4/13...congrats PROVENGE Kwidd 12/16/13 Joint pain for a week 1/2/14 - 2nd infusion PROVENGE Oncas     1st pheresis on 4/21/14 PROVENGE pepsiguy Summer, 2013 Questioned dosage… http://advancedprostatecancer.net/?p=4272 Some Doses of Provenge didn't meet Quality Standard PROVENGE samham55 Fall, 2013 12/30/13 - 2nd inf. Good Luck Sam!! PROVENGE Todd1963 2012 Completed Provenge: 6/1/12 PROVENGE turner 1/14/14   Triiple Luus Catheter, Completed 2/14/14; side effects: 1 st infusion: a bit tired, 2 nd – chills and aches, 3 rd – 12 hours of slight chills and major flu like aches/fatigue PROVENGE SteelGuy 12/23/13 PROVENGE wampuscat Jan. 2014 . Prostvac Trial PROSTVAC           Post Edited (Jerry L.) : 4/16/2014 6:44:35 PM (GMT-6)

Just joining the Provenge club.
Have my second cell collection tomorrow.
I appreciate all the great information shared here.

Sam

I'm still trying to get my HMO to cover Provenge treatment - next step is a hearing before the Review Board on January 22nd.

Add me to the Club ... Had one round so far 12/23 and will finish by later in January...

Chills during the infusion, but nothing later on. We'll see ... i'm starting a concurrent run with Zytiga in the near future. Can't let down my guard.

kwidd,

sorry for the delay...on the list...

How did the 2nd infusion go for you and how's the joint pain?

Jerry

Jerry L.,

I am sorry for posting on this threat ( I didn't have Provenge treatment), but I would like to point you a little mistake on your chart and think you maybe would like to correct it.

Pepsiguy didn't receive additional correct dose. He edited his post on 1/1/2014.:

"Well, I had my monthly visit to my Onc and he had not heard about this possible weak dose issue. Also, I'm in a provenge study and the gal involved in that hadn't heard about this so they pulled it up off the net. I guess I just alerted the Onc dept at the medical center. So I'm not sure where I stand but still hope to find out."

49packard on his threat Provenge posted email from his doctor's office that stated that this incident occurred 3 years ago:

"49 Packard

Please know that the above situation does not apply to our Provenge patients that have completed their therapy or currently receiving therapy. This was a very small percentage from 3 years ago and those practices that were affected have been notified.

Let me know if you have any additional questions.

Kindest regards,"

www.healingwell.com/community/default.aspx?f=35&m=2897641

My best Hope

Bob,

That's awesome.....

Updated...

JCRush was added...

Dev1,

That's awesome....thanks for checking in.

Wam,

I think I will change this to a Provenge / Prostvac Club.  We need your input....thanks

Devasted1 said...
I had two Provenge Treatments in March, 2010 and the third treatment in April, 2010. I was randomly selected for a fourth treatment which I received n July, 2010 (post RRP).

My last recent PSA test came up with non-detectable. What a miracle, for a Gleason 9, stage 4 can be and is non-detectable after four years.

Go Provenge.

Not a member of either club yet but had a question your post prompted me to ask.

I got the impression from Todd's blog that Provenge is normally 3 strikes and you are out, poor wording I mean that I understood that normally there are only 3 treatments whcih hopefully favorably affect any subsequent treatments with something else.

Also saw this topic today which is on point about order of treatments needs to be decided.

www.medscape.com/viewarticle/820421?src=wnl_edit_tpal&uac=206170AZ

It also mentions another drug in the pipeline "Tasquinimod"

"Currently approved options include sipuleucel-T [3,4] and abiraterone acetate. [5-7] Another drug, enzalutamide, [8] is approved after chemotherapy, but recent studies during the prechemo period have demonstrated a statistically significant benefit. One can expect that the US Food and Drug Administration will eventually give prechemo approval for that drug as well. Tasquinimod, an investigational drug, works by a different method of action from the 3 previously mentioned drugs. [9] Tasquinimod also has shown considerable promise in early studies, and we are awaiting the results from the phase 3 trials.

en.wikipedia.org/wiki/Tasquinimod

Another review of various treatment and the difficulty of deciding which order

www.medscape.com/viewarticle/819261?src=wnl_edit_tpal&uac=206170AZ

LupronJim

wampuscat and adjust added for Prostvac and changed the name to Immunotherapy instead of Provenge.

Devasted1,

In your study Provenge was used before the prostate was surgically removed and after prostatectomy researches looked at prostate, they found the T-cells had completely surrounded the tumor to kill it. But the most importate Provenge is still working inside you.
It is so delightful to read your report how you are doing after Provenge treatment.

I hope one day no only Provenge will be offered for all mCRPC patients ( it is a shame that only about 3000 patiens was treated in the USA in 2014, when can be eligible about 30,000 patients pur year ),but one day it will be offering for all PC patients in early stage of PC.

Some times I think if trial for Provenge didn't offer APC8015F "frozen Provenge" for placebo group ( crossover) and use patients only before CHEMO ( no mix pool before and after CHEMO) then real OS could be 12-13 months or maybe more :" Building on Sipuleucel-T for Immunologic Treatment of Castration-Resistant Prostate Cancer".

moffitt.org/research--clinical-trials/cancer-control-journal/from-bench-to-bedside-bringing-immunotherapy-into-the-clinic

or poster:

www.scribd.com/doc/73051542/ASCO-Poster-Prolonged-Survival-in-Control-Arm-Sip-T-Gomella-20111


Then all those "critiques" could not scream about " average 4 months" OS and many doctors would no offer only convenient pills for them ( like Zytiga ) and pass Provenge. What a difference could be in lives of those victims and their loves.


Wampuscat, Adjust,

If trials for Prostvac will be successful and this immunotherapy also will be offering to PC patients then will be the possibility of combining them or use one after another. You both can move to Provenge after those trials.

Here working link for Wampuscat's link :

clinicaltrials.gov/ct2/show/NCT01832870?term=provenge+ipilimumab&rank=1

and more on combination of Provenge + Yervoy you can read on Provenge ( part 1 ) on p 5-6:

www.healingwell.com/community/default.aspx?f=35&m=2487796&p=6


My best and many years ahead for all of you and your families, Hope