Barry,
The answer is not always. I had 2 previous biopsies, 1 14 years ago my PSA was 9.1 and the biopsy was negative. The other one was 10 years ago with a PSA 7.6, it was negative.
2 years ago my PSA was 18.5 but I ran out of luck with that biopsy.
Hopefully, your biopsy will be negative. They do take more samples now than they did 10 years ago so if there is cancer, they tend to find it better by taking more core samples.
Bill from Florida