Galeterone effective in controlling disease for subset of patients who have failed Xtandi and Zytiga

arthur-qa

Regular Member

Joined : Oct 2014

Posts : 118

Posted 11/20/2014 5:17 PM (GMT 0)

This was the conclusion based on a Phase II trial.

Now, a Phase III trial is in the works to further asses the effectiveness of the drug.

The idea is to eventually have a test, which will identify people who have the AR-7V receptor. Those who have it won't respond to Zytiga and Xtandi, so they would proceed directly to Galeterone (assuming Galeterone is shown to be effective).

http://www.ecco-org.eu/Global/News/ENA-2014-PR/2014/11/Galeterone-shows-activity-in-a-variant-form-of-castration-resistant-prostate-cancer

adjust

Regular Member

Joined : Jan 2013

Posts : 249

Posted 11/21/2014 12:29 AM (GMT 0)

Thanks for posting this arthur-qa! Very interesting to me, since Xtandi did nothing for me, and I suspect I may have the AR-V7 variant.

Here is your link clickable --> here

arthur-qa

Regular Member

Joined : Oct 2014

Posts : 118

Posted 11/21/2014 4:09 AM (GMT 0)

Here's another writeup on this news: prostatecancerinfolink.net/2014/11/20/can-galeterone-show-effectiveness-in-men-with-ar-v7-mcrpc/

A new Phase III trial is being initiated to compare Galeterone directly to Xtandi.

myman

Veteran Member

Joined : Feb 2007

Posts : 1219

Posted 11/21/2014 4:38 AM (GMT 0)

arthur-qa - Another thank you here! Will definitely be looking into this. Next appt 12/12/14 MRI & Bone scans & labs will tell story if taxotare continues to keep PSA & circulating tumor cells down.

Susan

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