How Does PCa Progress ?

I understand how PCa can spread itself via nearby tissue, lymph nodes and blood vessels.

What I don't know is how does it progress? The cancer obviously grows and becomes physically larger but does a G(3+3) cancer turn into a G7(3+4), G7(4+3), G8(4+4) and so on? Or does a G8 for example, start as a G8 and just get bigger in mass?

The "natural history" as it's called, is far from settled science. It seems likely that there are prostate cancer stem cells that give rise to daughter cancer cells of a single or multiple grades, but which grade can change over time, and the daughter cells have the ability to proliferate, and may be able to progress in grade as they do. All the various cell types influence one another and react to their environment. Certain cells may gain the ability to migrate from and thrive outside of the prostate, called epithelial-mesenchymal-transition (EMT). A lot of very complex molecular processes are involved that we are still learning about.

I realize this forum is a small fraction of the PC world. But!!!!, there has been more than one AS cass that has been upgraded to G7.

Thanks for this. I did more with Google and found additional studies that concluded the exact opposite of the Harvard study I noted. Go figure, can't believe everything you read on the Internet.

Clearly based on the track record here the progression from a G6 to a G7 happens.