Trimix Users - Challenges and Questions

I had a dual nerve-sparing, open RP 12/14 and have been on daily Cialis treatment since then. The only one who has benefited from the pills so far has been the drug supplier! My urologist recently announced that he wanted me to start using the Trimix injections to try and improve or at least maintain some functionality.

With backgrounds in chemistry, biology and medicine, my wife and I are used to dealing with drugs and the benefits/drawbacks associated with them, but had an expectation of consistency. So far the Trimix has been more challenging. The Dr has me titrating the dose of Trimix, starting at 0.1 ml and increasing by 0.05 ml each injection to identify the optimum dose. Overcoming the initial thought process about using a needle in that area, the next question was where to place the injection site for best "performance" and to avoid blood vessels.

So far I am up to 0.3 ml and have had a "response" at all doses. However, the excitement of the response dims as the injected Trimix "works". I appear to get about 60-70% erections, which are not quite ready for prime time. Also, the same dose on different days seems to give different results, with most of the swelling happening around the base, not the tip. I believe that the upper limit is 0.4 ml, so I feel like I am getting close and am concerned that I don't really want to visit an ER for this. :)

Can anyone provide input on their dosages, consistency and impacts based on injection locations? Is there a difference between standing and laying down? (Sorry, but I never mastered having sex standing up...)

For me, the actual firmness starts in about 10-15 minutes, and peaks about 30 minutes. It returns to a flaccid state about 1.5 to 2 hours after injection, so the 4 hour rule seems avoidable. However, even after it is flaccid, I can still feel the "pressure" for lack of a better term, for a while.

Also, how long does the Trimix really last when frozen? The pharmacy told me 45 days, but said that was actually from formulation to freezer to injection, which sounds weird to us.

Any feedback would be helpful!!

A few observations at random that might be helpful:

Men who get similar responses to a range of doses often have a venous leak and will need more of the drugs to get a usable reaction. Men with good venoclusion (no leak) have a fairly narrow line between not-enough and too-much. We have guys here who use 13 units (0.13ml) becasue 12 units produces very little result and 14 units keeps them rock hard for three hours. I, on the other hand, got similar results with anything between 25 and 50 units.

There are a number of strengths of trimix (different concentrations of the drug) and the one you are probably using is the one we call "watery starter mix". It is a good mix for starting out because men who are strong responders can do the necessary fine titration. Men with venous leaks (who need more of the drugs) often graduate to "trimix super" which is slightly more than three times as strong. If the stronger mix turns out to be appropriate for you you will find it less expensive per use even though it is more expensive per ml.

You may find that your response to the drug depends on your position. Most men get a stronger response when they are standing or sitting up straight than when they lay down. For men with a venous leak it can make a big difference.

A link that may help answer your questions follows.

I usually receive my trimix from the pharmacist frozen, and on occasion have kept it frozen for more than a year. I get a better price of I order in large quantities.

I have used trimix that has been refrigerated for more than a year ... No problems.

I use four units.

www.ustoo.org/PDFs/Injection.pdf

PeterDisAbelard. said...
A few observations at random that might be helpful:

Men who get similar responses to a range of doses often have a venous leak and will need more of the drugs to get a usable reaction. Men with good venoclusion (no leak) have a fairly narrow line between not-enough and too-much. We have guys here who use 13 units (0.13ml) becasue 12 units produces very little result and 14 units keeps them rock hard for three hours. I, on the other hand, got similar results with anything between 25 and 50 units.

There are a number of strengths of trimix (different concentrations of the drug) and the one you are probably using is the one we call "watery starter mix". It is a good mix for starting out because men who are strong responders can do the necessary fine titration. Men with venous leaks (who need more of the drugs) often graduate to "trimix super" which is slightly more than three times as strong. If the stronger mix turns out to be appropriate for you you will find it less expensive per use even though it is more expensive per ml.

You may find that your response to the drug depends on your position. Most men get a stronger response when they are standing or sitting up straight than when they lay down. For men with a venous leak it can make a big difference.

That last is not an exaggeration at all. My response always went from almost usable(regardless of dose) while standing to about zero response(except for ache) while laying down.

I am one where .01 is the difference between almost good enough for a half hour and ER trip.

My pharmacist officially says one month shelf life refrigerated, don't freeze. Unofficially, he says six months frozen should be fine.