Liver mets..

Which clinical trial is it? I know of a few where a PSMA antibody is linked to a cytotoxic drug, virus, radioactive substance, or something else that can kill the cancer cell it hooks onto. I think it has only limited efficacy by itself.

- Allen

Madeline, I don't know if this is of any direct relevance, but my daughter has been treated succesfully for liver mets from breast cancer for the last 20 months. The chemo used was Docetaxel, combined with Herceptin and Perjeta. Those last two items are used specifically for breast cancer, but Docetaxel (Taxotere) is used widely for PCa. I would expect that to be a first line treatment, but I am guessing you have already been through that?

Her inital treatment was 6 rounds of the combo, but because she tolerated it well, that was increased to 10 rounds. She is now on just Herceptin and Perjeta - and will be forever. Her mets initially shrank quite a bit (probably due to Docetaxel) and have remained unchanged on H and P.

Chas

Thanks for the replies.

He has been on Lupron, Taxotere, Taxotere with Carboplatin, Zometa, Jevtana, Xtandi, Zytiga and a few others I can't remember. Just about everything. It's such an aggressive tumor. I do not know the details of the PSMA Antigen. It is a clinical trial at Yale New Haven and they are meeting with the doctor tomorrow. It is a Phase 1 trial.

That would probably be this one:

/clinicaltrials.gov/ct2/show/NCT02202447

It's a PSMA antibody attached to tubulysin. Tubulysin is cytotoxic, so the hope is that the PSMA antibody will attach to the PSMA on the surface of prostate cancer cells, and the tubulysin will kill the cell it attaches to. Several kinds of chemotherapy, like docetaxel, also are effective because they affect the tubulin in cancer cells. The hope is that this agent will me much more specific to prostate cancer cells, and so will be less toxic to healthy cells.

It looks like an interesting trial. Please let us know how it turns out.

- Allen

Dear Madeline,

I owe you a debt of gratitude ...

Some months ago, you started a thread that you entitled "Taxotere Side Effects?" ...

After that, many of us here joined forces and began describing our collective experiences while undergoing chemotherapy treatments ...

The thread you started has reached "far and wide" ... helping MANY fellows here who were just getting started with chemotherapy treatments ... relieving them of some unfounded fears about chemo treatments ... suggesting ways to reduce side effects ... and providing a wide RANGE of chemotherapy experiences to prepare other fellows.

So, from across the miles, I just wanted to THANK YOU for starting that original thread ... it has reached MANY readers over time !

My thanks, my gratitude,
"Cyclone Fan" ~ Iowa State University