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Low PSA + lowfPSA% = higher aggressive Gleason score

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Posted 11/2/2016 9:45 PM (GMT 0)
Hello all.

I have a question that has been going around in my head for some time.(maybe from the beginning ). I have read in a few places that a lowPSA<4.0 combined with lowfPSA%<10 % can indicate highly aggressive higher gleason scores8-10. This was what happened with me (see signature) I have searched this on the search bar and on google and don't get much about this except that it can be the case. So I'm wondering how they tell one has an aggressive form of PC that doesn't respond as well to treatment.

As you can see my mind has already started to work overtime following my treatment

Thanks for any input

The Artistic One - Mark
Posted 11/2/2016 10:01 PM (GMT 0)
I did see this on a recent thread but it was not the subject title. I do remember Allen commenting but can recall who else was in the thread....I remember it because I had not seen this before myself. Hopefully someone on the thread chimes in.

Todd
Posted 11/2/2016 11:05 PM (GMT 0)
not going to answer the question.

Even if it is more agressive, you've already hit it with the biggest hammer you've got.

If the PC was confined to the prostate bed, you're done.

and you won't know that till you come off the HT.

chill, and wait. Unless, adding anxiety to your life was a goal.
Andrew
Posted 11/3/2016 12:27 AM (GMT 0)
I agree with Andrew. (I've been doing that a lot today.) I'd avoid going down that rabbit hole.

How long is your HT sentence for?
Posted 11/3/2016 12:55 AM (GMT 0)
I know you guys are right. It was just a long week with the surgery and when I get run down my mind gets running.

Michael_t -18 months more to go
Posted 11/3/2016 1:16 AM (GMT 0)
Do not know if this is of help but there are at least two rare subsets (small cell and Ductal) that have a tendency of not raising your PSA or even giving a positive digital exam until it is very advanced. They tend to be agressive and harder to treat, but part of that is the result that these forms are almost never caught in an early stage.

That is what happened to me. (The pathology showed it was Ductal.)
Posted 11/3/2016 4:13 AM (GMT 0)

Artist Mark said...
I know you guys are right. It was just a long week with the surgery and when I get run down my mind gets running.

Michael_t -18 months more to go

There is a lot riding on what happens when the HT wears off. I get that and I know how hard it is not to worry. can't say I do a great job at not worrying, but try not to worry and do stuff to distract your brain.

Hang in there, waiting is a killer,
Andrew
Posted 11/3/2016 4:30 AM (GMT 0)
The Artistic One - Mark,

From my signature, you'll have noticed that my PSA was 3.7 ( < 4.0) and I had a Gleason 9 (5 + 4). The aggressive cancer was discovered early, prostate was removed and for the last 3 years my PSA < .01.

The cancer was discovered early (ONE out of 16 needles) and I got lucky!
.
Posted 11/4/2016 10:08 PM (GMT 0)
Here's a link to some postings under "high Gleason, low PSA."

https://www.healingwell.com/sitesearch.aspx?cx=010904608862850737972%3Abe-6h9dblc4&q=high+gleason+low+psa&sa.x=29&sa.y=7&sa=Search&cof=FORID%3A9&siteurl=www.healingwell.com%2Fcommunity%2Fdefault.aspx%3Ff%3D35%26m%3D3735223&ref=www.healingwell.com%2Fcommunity%2Fdefault.aspx%3Ff%3D35%26p%3D2&ss=3766j1022926j20
Posted 11/5/2016 4:31 PM (GMT 0)
Hi Mark, this question used to bug me as well, as my dad was diagnosed with mets with a PSA of 7.5. I used to read a lot and watch many videos, doctors, etc, now I don´t have as much time. At one point, I remember one of the PC oncologists said that the low PSA and extensive disease may mean the aggressive kind of cancer, as people have mentioned, small-cell, etc. Then he said, but it is not always so. There could be low PSA and cancer that is still well-controlled. It turned out true for my dad, who is doing well after almost 6 years. He has adenocarcinoma, the typical histological type. Obviously, it is not giving out much PSA, why so - not sure, we will know more when genotyping of PC becomes a norm some time in the future. All the best.
Posted 3/2/2017 12:41 AM (GMT 0)

SpecialLady said...
Hi Mark, this question used to bug me as well, as my dad was diagnosed with mets with a PSA of 7.5. I used to read a lot and watch many videos, doctors, etc, now I don´t have as much time. At one point, I remember one of the PC oncologists said that the low PSA and extensive disease may mean the aggressive kind of cancer, as people have mentioned, small-cell, etc. Then he said, but it is not always so. There could be low PSA and cancer that is still well-controlled. It turned out true for my dad, who is doing well after almost 6 years. He has adenocarcinoma, the typical histological type. Obviously, it is not giving out much PSA, why so - not sure, we will know more when genotyping of PC becomes a norm some time in the future. All the best.

hi SpecialLady,

i know this isn't a recent post, but i wanted to say thanks as this post has given me some much-needed hope today. we will find out on friday if my dad's cancer is anaplastic/small-cell and it's good to see that someone else had low psa/high gleason and it didn't turn out to be one of these other cancers. i am worried sick.

my dad's is a gleason 8 with a psa for 4 at dx, despite a huge tumour mass. that's the highest his psa has ever been!

the doc is concerned as he has one spine met but a very low psa (just over 1 which then went down to 0.45 on its own) but we will know soon enough. i just need some peace and sanity in the meantime which is something i haven't had since this started last month. i know i can't will it away but this has given me some solace today. thank you.
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