High level PSA

Hello,

My first post here and, even if I know that my problem might look not as serious as many of the issues on this forum, I am quite scared and I need your advice.

I am 35 y.o. and during a routine check my urine sample results came out a little troubling as I had high levels of leukocytes and some traces of blood in urine.
Did a PSA test and the results : PSA 16.3637 , Free PSA : 1.1075 ->% 6.76
The diagnostic was acute prostatitis and the gave me 3 weeks of Levofloxacin and some other tests.
Was not able to find out the cause of a possible UTI (hoping that this is the case as I had some mild symptoms that might suggest that)
A month after first test and 1 week after the end of taking antibiotics I went for another PSA test.
The results : PSA 8,32 , Free PSA 0.677 -> % 8.13
I know it doesn't look good...

I was unable to find anywhere on the internet an information regarding the normal drop of PSA after a period of time after , let's say, a UTI or something like that. I've read that many PC cases had a drop in PSA after antibiotics but that did meant nothing in the end.

Does anybody know how much exactly should the PSA drop after certain periods of time (like for example 1 month) in cases of prostatitis ? Should've my level be in the safe area already ? Is it the case to go for a biopsy ?

Thank you in advance!

Welcome to HW.

Prostatitis is hard to treat and often doesn't respond to antibiotics. UTI and retention could also bump up the PSA. Typically PSA has a serum half-life of around 3 days. That you had a drop after the first round of antibiotics is a good sign. All things PSA tend to happen slowly and often just one test isn't enough - you need to look at the trend. If the trend is downward, cool, don't worry. An upward trend is a trip to the doc for answers.

Guess how much PSA should drop is a difficult game - too many variables to accurately predict. Likely you should wait another 3 months and retest. If it's lower, then you know the prostatitis is clearing.

Biopsy? You'd be one of the very rare cases to have PC at your age. In general, you want to rule out all other possible rises in PSA before even thinking biopsy. Honestly, I'd be surprised to find out that you have PC, even with the high PSA.

Wait, retest, and then see would what I'd do.

What did your doctor say about this?

I know that the thought of having cancer is scary, but PC is a different game. Even if the worst is true, you have so many treatment options that likely it won't be more than a health care bump in the road. There is every possibility of a cure and beating that.

Hang in there and keep us updated on your progress,
Andrew

Thanks you for your prompt and kind answers.

I didn't get the chance to show my second results to my doctor.
It's very frustrating how information is sometimes conflicting and not very clear about this PSA. Also it's worrying that doctors sometimes have different approaches and you can only hope that your doctor is taking the right decision.

I have utmost respect for you guys for your fight with this invisible enemy while I don't even have the courage to imagine how something like this would change my life...

Large increases and decreases of psa are symptoms of prostititis and not prostate cancer. Prostate cancer causes psa to grow at a steady rate over time.

Congrats.....what a great outcome and look at all of the knowledge you have gained. Hopefully knowledge you will never have to use.
If I had 35 year old knees and had your "news" I'd be doin' some dancin'

Hi new here.
Have been reading for a few months and appreciate the sharing of experience and insights.

I am 59 y/o and have had a baseline PSA of approx 1.4 for past 5 years. In June i got a UTI and dr treated with Levoflaxicin 750mg for 5 days that cleared the infection and symptoms but he added 500mg for 7 addl days to be sure. In any case i had a PSA jump to 4.7 in Aug and then 5.2 in Sept. He put me back on 500mg Levo for 28 days to see if that would lower.

So, my question is could UTI cause jump to 5.2 alone? Also should i ask for free PSA test also? Dr is cautious and old school. I will post new number in a few weeks test isnt until 10/20. The 28th day is 10/10 but dr said to wait aweek or so to test so antibiotic would clear my system.

Thanks for any insight or thoughts.