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New Keytruda clinical trial announced - a potentially great new immunotherapy

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Prostate Cancer
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Posted 9/23/2017 9:49 PM (GMT 0)
Husband started clinical trial at Dana farber in Aug. Keytruda every3 weeks and radium 223 every 4 weeks. Go Oct 2 for scans to see how it's working. Diagnosed May 2003. So many drugs trials and chemo to count. All in all doing ok
Posted 9/24/2017 3:31 AM (GMT 0)
Best wishes for a good response like my husband has had! Do you know whether your husband's cancer has the genetic signature that would have gotten him Keytruda outside the clinical trial (like mine?)

Anyway, keep us posted!
-- Carolyn
Posted 9/24/2017 5:33 AM (GMT 0)
what genetic signature . can u plz explain?
Posted 9/24/2017 2:47 PM (GMT 0)
Here's a link to the FDA approval notice. My husband had MSI-H in a lymph node biopsy - that basically means the DNA is really messed up (also referred to as hypermutated). The dMMR the article references are 4 DNA mismatch repair genes MLH1, MSH2, MSH6, PMS2. It's worth emphasizing that the genetic testing can't be done from a blood test (yet, I think, there may be circulating DNA tests that can do that eventually), but from a tissue biopsy.

/www.fda.gov/newsevents/newsroom/pressannouncements/ucm560167.htm

Hope that helps!

-- Carolyn
Posted 9/24/2017 4:47 PM (GMT 0)
Thanks for the link. I read the article, but its not feasible in every setting to perform genetic test first to start Keytruda. I am glad that it helped in your case. However, i had heard several trials are ongoing with keytruda in prostate cancer patients, i am waiting for the results so that i can plan it for my father.


There is always hope turn

Jannet
Posted 11/10/2017 3:54 AM (GMT 0)
This clinical trial is very similar to the original post, except it uses Opdivo, which is Bristol-Myers Squibb version of Keytruda, and a different PARP inhibitor, Rucaparib. It starts recruiting the end of November at 36 locations:

/clinicaltrials.gov/ct2/show/study/NCT03338790

The competition between big pharma benefits us.
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