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Question About Salvation Therapy

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Prostate Cancer
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Posted 10/1/2018 12:24 PM (GMT 0)
This question does not apply to me - but curious-
Why can't Saberknife - with its short 5 day regimine
Can not be used for salvation therapy
Would be great if it could !

Post Edited (Wotan) : 10/1/2018 6:28:03 AM (GMT-6)

Posted 10/1/2018 2:27 PM (GMT 0)
You mean Cyberknife? I guess nobody knows if it is feasible for ART/SRT yet. It could be! It has just not been tried out in enough number of trials. Efficiency and toxicity are not known.

Here is one clinical trial that evaluates the feasibility of SBRT post-prostatectomy with 5 treatments.
/clinicaltrials.gov/ct2/show/NCT02976402

Previously untreated patients who underwent radical prostatectomy with adverse pathologic findings will be enrolled in a phase I study, consisting of 31 Gy (5 fractions of 6.2 Gy), respectively, delivered over a 1-week period at 5 fractions per week. This dosage corresponds to 68.2 Gy (for an α/βratio estimate of 1.5 Gy), compared to 52.7 Gy (for an α/β estimate of 4 Gy) in a conventional schedule. In those who developed early biochemical failure the radiation schedule will consists in 32.5 Gy (5 fractions of 6.5 Gy), respectively, delivered over a 1-week period at 5 fractions per week. This dosage corresponds to 74.3 Gy (for an α/β ratio estimate of 1.5 Gy), compared to 56.9 Gy (for an α/β estimate of 4 Gy) in a conventional schedule.
Posted 10/1/2018 2:56 PM (GMT 0)
Cyberknife (SBRT) has been used successfully for salvage prostate cancer treatment in some studies.

https://www.renalandurologynews.com/prostate-cancer/stereotactic-body-radiation-therapy-shows-effectiveness-for-oligometastatic-prostate-cancer/article/786191/

If you google "SBRT prostate cancer salvage" you will find several articles about using SBRT for salvage treatments, after either failed surgery or failed radiation.
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