Recurrence instances are highest after 5 years from the surgery

Hi to everyone.

Is it true that the risk of recurrence, is the highest after 5 years from the surgery?

Post Edited (Zeddy) : 5/18/2019 6:53:47 PM (GMT-6)

It depends how you phrase the question and what exactly you're looking for.

Its pretty clear looking at study after study that recurrence rates drop over time. The majority of the recurrences occur over the first few years.

While you DO have late recurrences at 10 or even 15+ years they aren't as common for folks that have made it that far compared to say everyone during the first few years.

I would be more concerned about recurrence in years 1-2 than I would in years 5-6.

ddyss said...
https://www.mskcc.org/nomograms/prostate/post_op

Best way is to look at the nomogram with your specific inputs.

Thank you. This is a great help. I'll do it straight away.
Well, with my figures the result is:
recurrence free at 7 years 99%, and 98% at 10 years, so the risk increases by 1%

Post Edited (Zeddy) : 5/19/2019 4:56:07 AM (GMT-6)

no it is not...and studies are inherently by definition wrong...whose definition...All epidemiologists and every one that creates a study...knows this...it is a study...if they were right...you would not have to ever have another study about them...the problem would be solved...it makes perfect sense if you THINK(not a shout...emphasis) about it...not directed at the individual who started this thread.... a thread about this might shed some light on this to the members...I wont be starting it however
PS the 4 words that start this post is directed at the threader of this thread...not a slam...I mean the question as stated deserves the answer the I gave it( the first 4 words) in this sense...as written they both are meaningless...someone posted words to that effect.., nothing wrong with that...me...I like some ooph in my responses...it percolates better imo..

Zeddy said...
Oh by the way, does anyone know all the other body organs that produces PSA? I only know of salivary glands.

Zeddy,

Don't know about *all* of them, but below are *some* more...

From this older document:

http://clinchem.aaccjnls.org/content/clinchem/41/1/7.full.pdf

"However, as with many stories in biology, the tale of PSA’s specificity is more interesting and complex than was first appreciated. The discovery that PSA could be detected by immunohistochemical methods in female
periurethral glands ended the notion that PSA was absolutely specific to prostate, semen, and gender (13, 14).

Using similar methods, later investigators found that PSA could be detected in apocrine sweat glands, apecrine breast cancers (15), and salivary gland neoplasms (16)-further confirming PSA’s lack of absolute tissue and gender specificity. PSA recently has also been detected in the periurethral and anal glands of men (17, 18). Its presence in the urine of men after cystoprostatectomy (19) indicates that the male urethra is an- other small but measurable tissue source for PSA."


And this document provides more research on the peri-urethral source (you have to page down a few pages in the link to get to the full text):

https://www.researchgate.net/publication/47447046_what_are_the_possible_reasons_for_urethral_psa_varieties_after_radical_prostatectomy


Hope this helps.

Robert

Depends on how you look at it. The longer you go without recurrence, the better. However, there is no absolute clear time period from what I can tell with PCa such as making it 10 years and you will never get PCa again. It seems that most recurrence occurs within 5 years after treatment if it is going to happen but there are so many cases over 5 years that the 5 year mark does not mean much in the bigger picture. Only takes a few rogue PCa cells floating around to start another cancer which may take years to detect. What was the question again?

Hi Robert and thank you very much for a great reply. You've answered everything I wanted to know, regarding this subject. Obviously all these different sources of PSA will have some effect on uPSA (Super sensitive PSA) measurement ??!!
Thanks again

Frederick

Post Edited (Zeddy) : 5/19/2019 3:53:08 PM (GMT-6)

You just want to take advantage of the new guy... My mom warned me about you guys when I get older.

Our ability to cause (certain kinds of) harm vanished with our prostates ;)

Zeddy...me lad...you are right I care zip...zero...nada...about Pca......To answer the other part of your question...why are you still here...I could quote Fonda from Grapes of Wrath...I could quote John Wayne from the movie Wings of an Eagle...(im gonna move that toe...Im gonna move that toe)...I could quote Willy Sutton...Why do you rob banks...cause that's where the money is...I could quote all the quixotic quests from Here to Eternity...but I know...I fricken fracken know that all here awreddy know(even you)...so why push the river...or the giver...the stones are polished...no need no joker lips from Barcelona or Dallas...

Read Dr Meyers, when recurrent PCa isn't cancer. May shed some light on low PSA numbers after RP.

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"me lad" ??? oh Daddy, I didn't know you are English !! You watch too many movies !
I swear ... hands on heart and hope to die if I lie .. I really don't know ... please shed more light on it.
..... or let's go and continue the poker in the back room. Hell with PC

Post Edited (Zeddy) : 5/20/2019 3:18:53 AM (GMT-6)