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"Vision" Trial, NCT03511664, Lu-177, Now Closed..

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Prostate Cancer
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Posted 9/15/2019 1:35 AM (GMT 0)
One of the very promising new treatments for advanced PC was running a large clinical trial which allowed a large number of patients to receive the Lu-177 radioisotope treatment has reached its participant goal and is no longer recruiting new participants..The next milestone will be whether or not the FDA will approve this treatment for advanced or any other form of prostate cancer..I was lucky enough to be accepted into the trial 2 months ago and so far it has been very effective for me, dropping my PSA by 65% in just 7 weeks..
Posted 9/15/2019 2:20 AM (GMT 0)
That's great Fairwind! And I'm glad you got in. High hopes for continued good results.
Posted 9/15/2019 11:47 AM (GMT 0)
Yeah, I have been watching the Lu-177 treatment advance with great hope as it has proven beneficial to some GB cancer patients.
Posted 9/15/2019 1:02 PM (GMT 0)
This is great news, another treatment that can extend life and keep the beast at bay.
Posted 9/15/2019 7:36 PM (GMT 0)
Yes, this is a very exciting trial. Reading the post today by LuvmyDAD and their experience with this treatment encourages my belief that early treatment is best, at least sometimes and for some patients who want it. He has widespread bone mets which means a lot of the radioactivity went to bone marrow which is where the platelets are made. The radioisotope killed platelets as well as prostate cancer cells. For a patient with much less bone metastasis, hopefully, the medication would be much less toxic to the bone marrow. So hopefully this medication will soon be approved for early disease treatment rather than waiting until the patient has run out of other options. But we'll have to wait to see how the study turns out.
Posted 9/16/2019 1:31 PM (GMT 0)
That's great news Fairwind. You really deserved a break. It's wonderful that this promising theranostic has been extended to other cancers since I first heard about the COMPETE trial about a year ago during my introduction to the world of neuroendocrine cancer.

Lutathera (Lutetium Lu 177 Dotatate) First Radioactive Drug Approved for Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs), also known as carcinoids and islet-cell tumors, are tumors of the neuroendocrine cells that occur in the gastrointestinal (GI) tract. Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-Edotreotide (PRRT) radiopeptides was approved for the treatment of somatostatin-receptor-positive GEP-NETs, including foregut, midgut, and hindgut tumors in adults. PRRT has been used extensively in Europe over the last few decades.

We all need to exercise our vocabulary beyond existing boundaries now and then... you know, to help combat the effects of Lupron brain.
Posted 9/16/2019 1:37 PM (GMT 0)
Great news
Posted 9/18/2019 7:34 PM (GMT 0)
Darn, I was hoping to be able to get in on this trial. In fact, I am scheduled to visit with my RO who is a part of the study in 2 days. I don't know if he has any sort of "pull" but maybe I can get lucky. Otherwise, Xofigo, I guess.
Posted 9/20/2019 1:57 AM (GMT 0)
If you have the money, you can travel to Germany or several other countries and get the Lu-177 treatment which they consider to be standard treatment for those who can afford it..
Posted 9/20/2019 11:26 AM (GMT 0)
Please keep us updated on your progress. Lu-177 gives us some hope, as do related endeavors.
Posted 8/22/2020 9:48 PM (GMT 0)
Fairwind,
How are you doing? It looks like my Xtandi isn't working as we'd hoped. After Zytiga seemed to have run its course and the PSA got up to 2.7 (from 0.5). After 4 months on Xtandi, PSA has climbed to over 7 and the next step is likely LU-177. I had a PSMA scan at UCLA last month, and will hope the LU-177 becomes available here. Curious how the LU-177 went, and how you're doing now. Did you stop Lupron and other meds when you went to the trial.

You and I have similar situations and I always look forward to your posts. Hope you are well and look forward to hearing from you.
Posted 8/23/2020 4:21 PM (GMT 0)
Also following this thread for updates and very hopeful that LU-177 is found to be a treatment that can be added to standard treatment protocols in the USA. I really hope it is working for Fairwind and sending my best wishes to you steve55777 that your team will find the right mix soon.
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