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Zytiga and Kidney Issues

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Posted 12/4/2019 9:55 PM (GMT 0)
Received a call from my MO early this morning. That’s never good. Apparently the Zytiga and Pred I started a couple of weeks ago is frying my kidneys. MO advised I stop taking all Rx’s as well as all supplements (other than BP Rx). Kinda bummed since I had high hopes for Zytiga working for me with the eligard shots. The MO wants to see me on Monday and repeat bloodwork but something has gone awry. Hoping to discuss Xtandi as another option. Dang it! Very disappointed.
Posted 12/4/2019 10:20 PM (GMT 0)
One reason I selected Xtandi was to avoid the Prednisone - though I don't know if it has anything to do with your kidney issues. Good luck with the MO appointment!
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Posted 12/4/2019 11:43 PM (GMT 0)
The prednisone is only a replacement dose for things that zytiga depletes. But I know my MO watches liver and kidney blood tests closely because zytiga can cause problems for both.
Posted 12/5/2019 1:04 PM (GMT 0)
There are some options with Zytiga that you can talk over with your doctor. Sometimes men are able to drop back to a half dose and gradually build back up to a full dose. Another option is taking a half dose with food. I think the recommendation is a low fat breakfast but I'm not sure without doing some research. There are also come doctors out there that believe the full dose is too much and that a half dose works just as well.

I'm sure there are a lot of recommendation on this forum - you may want to review the Zytiga post that has a lot of collective experience.

If you are on a lot of other prescriptions you may want to check those for kidney side effects. Statins, for example, list kidney side effects. You may be able to switch some of those to another drug to help take the load off your kidneys.

Good luck!
Posted 12/5/2019 4:19 PM (GMT 0)
I forgot to mention I was on half dose zytiga for awhile and have been on 3/4 dose for over a year. Those are options too as Union98 points out.
Posted 12/5/2019 10:29 PM (GMT 0)
Thanks for the replies. I’m scheduled for some tests tomorrow, kidney function, CT, and abdominal ultrasound. I’m hoping the MO has results by Monday. I had to chase these tests down myself today. Apparently STAT has changed meaning. Thought it meant immediately but apparently now it’s Sure Takes Along Time. Anyhow, starting tomorrow at1:30 and see what theMO thinks. I’d be thrilled if a decreased dose with food would be an option. Will keep y’all posted...
Thanks again...
Posted 12/25/2019 6:40 PM (GMT 0)

Keep us posted on what you find out. This is an important topic.

I have been on ZYTIGA, continuously, for over 50 months now. On a whim, I started saving my empty prescription bottles, as a way to track my progress on ZYTIGA.

I hope a new path forward can be trailblazed for you --- different dosing options, or considering XTANDI instead, for example.

I hope that in the future, these newer breakthrough medications that many of us have pursued will also be redesigned to lessen, alleviate, and eliminate side effects, for one and all.

Let us know how you're faring --- we'll keep the front porch light on for you in the New Year ahead!
CYCLONE ~ Iowa State University
Posted 12/25/2019 7:30 PM (GMT 0)
Thanks for the reply Cyclone-ISU and the well wishes. It’s awesome that this drug has worked so well for you. I can only hope to be so fortunate. After receiving the results, Almost two weeks ago the MO put me back on Zytiga and Pred. No change in dosage but took me off Celebrex and told me to stop ALL supplements. No NSAIDS at all. The first week back on was a bit rough with worse side effects than the first time but my body seems to be adjusting. I had bloodwork this past Monday and my first Xgeva shot. Due to the Holiday I haven’t got this weeks results to see how the kidneys are doing but my PSA is now <0.1 For the first time in about two years. Also, today is the first day in a long time that my bone Mets are hardly noticeable and no pain killers. I’m calling it this year’s Christmas miracle. Hoping to be able to continue the Zytiga and I’ll keep you posted as I get more results. In the meantime, I wish everyone a very Merry Christmas and a Happy New Year! Blessings to all.
Posted 12/26/2019 3:37 PM (GMT 0)
Update: Just heard from the MO and he is stopping the Zytiga/Pred. Creatinine is up again. He said he’s never had a patient have this issue and is referring me to a nephrologist for a work up. In the meantime, he is going to switch me over to Xtandi and will get that ordered. The wife and I have a cruise coming up and he wants me to hold off starting the Xtandi until we get back. Wouldn’t want to be in the Caribbean and have a problem! So, that’s where I’m at for now.
Posted 12/27/2019 1:09 AM (GMT 0)
Thanks for the update. So sorry you had Zytiga trouble. Enjoy the cruise and come back better than ever ready to go with Xtandi.
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