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zytiga food ??

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Posted 3/14/2020 1:55 PM (GMT 0)
day 9 on the big Z no side effects read everything in Cyclone's wonderful thread on the big Z nothing on things not to eat coffee no cream no sugar (why) I drink milk I eat some sugar. thanks to all NEPOL.
Posted 3/15/2020 1:46 AM (GMT 0)

Hello Nepol!

I'm thankful you found the Zytiga thread. Many comrades here worked together to document their experiences with Zytiga ... and now the newer approved generic versions, as well.

To answer your question ...

My prescription for ZYTIGA states that I need to take the medication on an empty stomach --- no food two hours prior. So, for me, it's easiest to take the tablets first thing in the morning, when I wake up and start my day.

My prescription states no food for an hour thereafter. That time goes quickly, by the time I get showered and dressed and ready for my day.

One hour later, I then consider the rest of the day MINE. I then eat and drink what I wish. By then, the medication is absorbed into my system.

By the time I arrive at work, the one hour has elapsed. Weekend mornings, I often take my medication first thing in the morning, then head out on a morning walk. When I return, I then eat or drink what I wish the rest of the day and evening.

I do drink water while taking the medication. I wait a few minutes between each pill, with sips of water in between.

This is because one morning, I was really in a rush, and "wolfed down" the 4 tablets in quick succession. An hour later, I was nauseated and had the dry heaves. I won't make that mistake again. Lesson learned!

So I always sip some water, take a tablet, and continue getting ready for work, as I continue taking all 4 tablets, one at a time, a few minutes apart, with sips of water in between times to avoid any possibility of nausea. This method works!

By the time I arrive at work, the hour has already elapsed --- and the rest of the day is mine to eat or drink as I wish. If there's doughnuts in the staff lounge, those are fair game by then, right?!!

Sometimes, on weekends, I meet up with old friends for breakfast at a favorite cafe. I just make sure I have taken my Zytiga tablets an hour BEFORE arriving at the cafe. By the time I arrive, I'm ready to place my breakfast order!

All of these things have simply become part of my daily routine. I have remained on ZYTIGA (and now the generic version) for about 55 months now. My morning ritual ...

I still keep the empty medication bottles lined up on a shelf, to mark my progress, and feel a deeper sense of gratitude for this breakthrough medication that has helped me over time.

With my best, from across the miles,
Cyclone - Iowa State University
Posted 3/16/2020 12:40 AM (GMT 0)
thanks for the come back CYCLONE ! going to leave a line or 2 on that big Z thread good day NEPOL
Posted 3/16/2020 11:04 AM (GMT 0)
Nepal,
One thing I would like to add. As your blood is monitored over the months and years to come, keep an eye out for lowering potassium levels. I don’t know what causes it but my potassium levels are chronically low. I supplement and I do feel better but due to lupron fog sometimes I forget why I feel sick or why my muscles are cramping. Just something to think about. Todd

Post Edited (Todd1963) : 3/19/2020 10:24:13 AM (GMT-6)

Posted 3/17/2020 1:50 PM (GMT 0)
Todd -- it's morning in the mountains couple feet of snow graded my drive way yesterday. then I remembered I didn't tell 1968 thanks for the tip ..when I read it I went looking for foods that held a lot of it .. thanks for the response NEPOL
Posted 3/19/2020 4:22 PM (GMT 0)
Your welcome
Posted 3/20/2020 6:22 PM (GMT 0)
A just-published PK study:

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme (2020, Full Text)

"Highlights
• Prospective study on therapeutic drug monitoring (TDM) of abiraterone.
• Concomitant intake with food resulted in a significant increase in Cmin.
• Cost-neutral opportunity to optimise exposure in patients with low Cmin.
• Pharmacokinetically guided dosing led to target attainment without extra toxicity.
• The effect of TDM on efficacy will be evaluated in a larger patient cohort.

Abstract
Aim
Abiraterone acetate is approved for the treatment of metastatic prostate cancer. At the currently used fixed dose of 1000 mg once daily in modified fasting state, 40% of patients do not reach the efficacy threshold of a minimum plasma concentration (Cmin) ≥ 8.4 ng/mL and are thereby at risk of decreased treatment efficacy. This study aims to evaluate whether pharmacokinetically (PK) guided abiraterone acetate dosing with a food intervention is feasible and results in an increased percentage of patients with concentrations above the target.

Methods
Patients starting regular treatment with abiraterone acetate in modified fasting state were included. Pharmacokinetic analysis was performed 4, 8 and 12 weeks after start of treatment and every 12 weeks thereafter. In case of Cmin < 8.4 ng/mL and acceptable toxicity, a PK-guided intervention was recommended. The first step was concomitant intake of abiraterone acetate with a light meal or a snack.

Results
In total, 32 evaluable patients were included, of which 20 patients (63%) had a Cmin < 8.4 ng/mL at a certain time point during treatment. These patients were recommended to take abiraterone acetate concomitantly with food, after which Cmin increased from 6.9 ng/mL to 27 ng/mL (p < 0.001) without additional toxicities. This intervention led to adequate exposure in 28 patients (87.5%).

Conclusion
Therapeutic drug monitoring of abiraterone was applied in clinical practice and proved to be feasible. Concomitant intake with food resulted in a significant increase in Cmin and offers a cost-neutral opportunity to optimise exposure in patients with low Cmin."

(See Full Text)

Post Edited (DjinTonic) : 3/20/2020 12:35:45 PM (GMT-6)

Posted 3/24/2020 9:35 PM (GMT 0)
djin tonic blue click would not happen, but you gave a good break down. i read somewhere in here a doctor changed someone's script with low fat meal going to talk with doc, April 7 thanks for info NEPOL
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