Interesting Mayo study: Intermittent Fasting and PCa Recurrence

It's interesting that this study is using 0.4 as their definition of BCR.

"Following a daily fasting routine after treatment for prostate cancer may lower the risk of patients' PSA level rising above 0.4 ng/mL, which is also called PSA-recurrence. A PSA-recurrence can sometimes mean that the disease has returned and/or progressed."

When institutions were looking to set a definition of "official" BCR, Johns Hopkins originally proposed 0.4 for the reason that a number of men see their PSA increase and then plateau. I haven't come across 0.4 in recent papers.

One thing jumps out at me in the Inclusion Criteria:

"Men that decline adjuvant therapy"

This seems to go against their recruiting only pT2 men or PT3 if specimen confined. I think including men who decline adjuvant will work against their having good overall results, but I'm sure outcomes will be broken down by cohort, and it will be good to know if the fasting works for them, too.

Djin

I've been doing IF for weight loss and it works well. There is a lot of speculation on the internet about IF helping to fight cancer but its not recommended by doctors. Glad to see Mayo at least looking into it.

My wife spent nearly a year with a modified version of this. She ate only within a 10 hr window. No effects that we could detect. I'll mention the more rigorous plan and see if she'll continue speaking to me.

Running trials aren’t inexpensive, I would be interested in why thy think it may be beneficial.

This is very interesting.

I eat one meal a day. It’s usually healthy. I’m hungry but do not eat. It’s a frame of mind thing that keeps the weight off.

Very interesting.

Edit...the bounces were when I weighed too much and eat what I wanted. I went to over 200 lbs. (First time in my life). A year ago is when I quit eating. Just not eating is the only way for me to stay healthy weight wise. (I’m an “on or off” kind of guy anyway...in other areas of my life as well. Moderation has never been my goal lol).

I’ve weighed in the 170’s for a year now. When it gets down to the low 170’s, it concerns me. So, I will intentionally begin grazing on healthy stuff during the day until it picks back up to 177 to 178. Once there, I back it off again and start it back down. This isn’t diet for me. It’s frame of mind. Currently, I’m on a “downward trend” again. It went to 178 a few weeks ago. When I weigh that much I begin to “feel fat”. I’m around 174 now. It gets to the point of being able to tell within a pound or two of what I weigh without weighing. I’ve not eat anything but fruit last night in the last 36 hours. I’m hungry this morning but will not eat. That hunger feeling is something like I need it. Can’t explain it more than that. But, it’s like it keeps me from feeling fat. And feeling fat makes me feel old. I don’t wanna feel old. So, I don’t eat.

This is indeed very interesting. And those of you who know anything about me will not be surprised that I found this quote from Bobbiesan's post especially interesting: ""Similarly, intermittent fasting is thought to impair energy metabolism in cancer cells, inhibiting their growth and rendering them susceptible to clinical treatments. The underlying mechanisms involve a reduction of signaling through the insulin and growth hormone receptors.............".

I've been pounding that insulin table for a long time. I'm hoping their trial will show some benefit for PCa, since I have been playing around with that approach for a while now. It will be impressive if the 16 - 8 eating pattern helps any, since one thing I'd like to see evidence on: how many hours of fasting are required to see actual health benefits, especially how many hours does it take for autophagy to begin? On my fast days, I usually shoot for supper to supper, though sometimes I just do supper to noon - 2PM.

I wish I had the will power to switch that breakfast to breakfast, or lunch to lunch. I have seen some evidence that skipping supper is more effective than skipping breakfast. And that there is twice as much insulin response to consumed carb at night as their is in the morning. But, my wife usually cooks good suppers and if I am going to skip, it seems easier to skip earlier in the day, looking forward all day to that good supper. I'm convinced that I do not consume enough calories at supper to even come close to making up for what I missed during the day. It seems to me as though my stomach shrinks and I get really full quicker after a fast.

Today, I may continue my morning fast until after lunch and eat some chicken livers and nothing else, no carbs until supper. Not only is that a very low carb food, it is loaded with vitamin A. It could just be my imagination, but since I have increased A ( to go along with my good amount of D), minor certain skin issues have suddenly improved. Like little bumps and keratosis that pop up and such. Also, my Rosacea ( auto immune ) seems much improved lately. I have had that for MANY years, having received no improvement from the prescription drugs I once tried years ago. OTOH, I do so much DIY stuff, if these things actually have improved, who can really say what caused it? For that matter, intermittent fasting may have supplied the majority of the improvement.

Post Edited (BillyBob@388) : 8/19/2020 7:17:48 AM (GMT-6)