What does “cribriform present” mean?

Hi Djin, thanks for your valuable information on cribriform and other suggestions. Thanks all buddy for your warm encouragement.

DjinTonic said...

logoslidat said...
I realize that this may fall on deaf ears...but here goes...for once oh wise and caring forum members...can we let... what appears to be a a smart fellow...quite up on his heath awareness regimen...just for once...let himself choose his treatment...now that would be a breath of fresh air for most...yada yada blah blah...

No, we are going to organize a team of Healingwell brothers to restrain him and administer the majority Forum treatment choice.



Djin

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Good plan! LOL!

116, as Djin said, we all felt like our lives were in a mess when we were diagnosd. So we understand. KEEP IN MIND, that Prostate Cancer for most men, even aggressive cases, is usually treated as a chronic disease, if not cured with initial treatment.
So chances super high that you have many more years, no, many more GOOD years, to enjoy life ahead of you, and you will look back on this as a bump in the road.
As far as your original question, nothing i can add to the excellent comments you have already received. Please keep us informed and good luck.

Sorry, didn't mean to hijack the thread, but while on the subject of biopsy report, does anyone know what this means after cribriform comment:
" The presence of tumor in skeletal muscle, as seen in this case, does not necessarily indicate extraprostatic extension".

chad91 said...
Sorry, didn't mean to hijack the thread, but while on the subject of biopsy report, does anyone know what this means after cribriform comment:
" The presence of tumor in skeletal muscle, as seen in this case, does not necessarily indicate extraprostatic extension".

This is news to me, but a quick search turned up the following.

Should the involvement of skeletal muscle by prostatic adenocarcinoma be reported on biopsies? (2016, co-authored by J. Epstein, the dean of prostate pathology)

"Abstract
Skeletal muscle is seen at the distal part of the prostate apex, where benign glands may reside as part of normal anatomy and histology, and extends more proximally anteriorly. At times, prostatic adenocarcinoma can be seen admixed with skeletal muscle, raising the question of extraprostatic extension. Although there has been increased attention regarding biopsy sampling of the distal apex to guide the performing of the apical dissection on radical prostatectomy, the finding of skeletal muscle involvement by prostatic adenocarcinoma has not been consistently reported by pathologists on biopsies. We searched our database spanning 12 years from 2000 to 2012 for all patients who had prostatic adenocarcinoma Gleason score 3 + 3 = 6 involving skeletal muscle on biopsy. We identified 220 patients who met the criteria. Of the 220 patients, 101 underwent prostatectomy, which comprised the "study group." Prostatectomy reports from these patients were compared with those of a "control group," which consisted of 201 contemporaneous patients with Gleason score 3 + 3 = 6 prostatic adenocarcinoma on biopsy without skeletal muscle involvement. The results showed a significantly higher percentage of positive margins in the study group compared with the control group (P = .006). The study group also had a higher percentage of positive margins at the apex admixed with skeletal muscle (P = .008). In summary, the findings in this study support that pathologists should report the involvement of skeletal muscle by tumor, and recommend that urologists performing radical prostatectomies on these patients try to ensure adequate excision in the apical area to avoid positive apical margin."

[Emphasis mine]

Djin