Checkmate 650 immunotherapy trial

RobertC

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Posted 10/11/2018 1:20 PM (GMT 0)

/www.uchicagomedicine.org/cancer-articles/an-unexpected-success-for-cancer-immunotherapy-treating-prostate-cancer

This is an article on Checkmate 650 trial of 2 immunotherapies. I hope it was not posted before.

Brief Summary:
The purpose of this study is to determine whether nivolumab plus ipilimumab has preliminary evidence of safety and effectiveness in treatment of metastatic castration-resistant prostate cancer

/clinicaltrials.gov/ct2/show/NCT02985957

Post Edited (RobertC) : 10/11/2018 7:23:45 AM (GMT-6)

Sr Sailor

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Posts : 1483

Posted 10/11/2018 2:52 PM (GMT 0)

That press release is promising, but is based on one (1) patient. Let's hope for more good outcomes from this and similar trials.

InTheShop

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Joined : Jan 2012

Posts : 11468

Posted 10/11/2018 6:26 PM (GMT 0)

I have a lot of hope for immunotherapies. Hopefully this one goes the distance.

Andrew

Saipan Paradise

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Posted 10/11/2018 7:04 PM (GMT 0)

Here’s a nice CRI webpage discussing advances in immunotherapy for PCa (touting their own researchers, of course) and breaking down the current immunotherapy clinical trials by mode of action:
/www.cancerresearch.org/immunotherapy/cancer-types/prostate-cancer

Sr Sailor

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Posts : 1483

Posted 10/11/2018 11:51 PM (GMT 0)

As an aside, the development of both 'drugs' came from fundamental research in immunology. Not from research directed at wiping out cancer.
The research of 2018 Nobel Prize winner Allison, 70, ultimately resulted in ipilimumab (Yervoy)
and the work of the other Nobel prize winner this year (Honjo, 76) resulted in nivolumab (Opdivo).

In the trial mentioned above both drugs are combined.

science.sciencemag.org/content/362/6410/13

Post Edited (Sr Sailor) : 10/11/2018 5:56:42 PM (GMT-6)

Jerry L.

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Posted 10/13/2018 2:29 PM (GMT 0)

Thanks for the info. Sounds very promising. I find it interesting that PC was the first cancer to have an approved immunotherapy (Provenge), but many more strides with other cancers with this type of therapy.

FoxRun

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Joined : Aug 2011

Posts : 894

Posted 10/17/2021 1:57 PM (GMT 0)

Hi All,
Anything new to report on this therapy?

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