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Piperlongumine Herbal anti-Cancer

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Posted 11/20/2021 4:27 AM (GMT 0)
Just want to give a heads up about some interesting reading I've been doing about Piperlongumine.
It is what is believed to be the active component of piper longum, or long pepper. Grown in Tropical regions it has been used as a medication and food spice for thousands of years. Recent articles on it have been very positive about its anti-cancer activities.
They sell piperlongumine pills on Amazon, but they also sell (and I prefer) piperlongumine powder and piperlongumine tincture.

For example, see Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage. (2021)
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-021-03369-0

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Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells (2012)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491117/

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Piperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells
https://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=5;spage=216;epage=223;aulast=Kismali

"Results: Piperlongumine inhibited cell proliferation at low doses (<10 μM) alone and in combination with TRAIL (25 ng/mL), induced apoptosis, and suppressed cyclooxygenase activation. Additionally, piperlongumine induced expression of death receptors which potentiated TRAIL-induced apoptosis in cancer cells but did not affect decoy receptors. Piperlongumine also downregulated tumor cell-survival pathways, inhibited colony formation and migration of cancer cells alone or in combination with TRAIL. The combination of piperlongumine with TRAIL was found to be synergistic.
Conclusions: Our findings indicate that piperlongumine can sensitize cancer cells to TRAIL through the upregulation of death receptors and can trigger apoptosis with the downregulation of anti- apoptotic proteins."

https://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=5;spage=216;epage=223;aulast=Kismali
Posted 11/20/2021 12:07 PM (GMT 0)
Say what?
Posted 11/20/2021 2:19 PM (GMT 0)
Good to see you Halbert

I don't get the "say what"

I think herbal "remedies" should not be used in place of Western Medicine, but neither should they be ignored. Some of these have been developed over thousands of years, and I would imagine medicinal plants were cultivated and
subject to selection by those using them, meaning there has been evolutionary pressure in the direction of effectiveness.
Posted 11/20/2021 4:05 PM (GMT 0)
Interesting science, for sure. Any progress towards a clinical approach?
Posted 11/20/2021 4:13 PM (GMT 0)
When I see "herbal cancer prevention" I respond with "yeah, right". Along with claims about vitamin cramming, supplements, special diets, etc.

Sorry, not buying it.
Posted 11/21/2021 4:50 PM (GMT 0)
Halbert: [Sorry for the length; I got a bit carried away]
If you're talking about using Eastern Medicine in place of Western I agree with you. I do however think that over thousands of years enough empirical knowledge was built up that using Eastern Medicine as an adjunct is advisable. Until recently Western medicine pretty much ignored Eastern. I think that was a mistake.

Concerning diet, the evidence is in (and overwhelming) that a plant based diet is the best (though you need to make sure you're getting enough protein). I don't understand why I needed to learn this from books and Clinical Trials but my ONC never mentioned it.

I didn't mention acupuncture but I can tell you that when I was on Abiraterone I was wiped out. Went to an acupuncturist and after two or three treatments felt noticeably better.

These herbal remedies were developed over thousands of years and presumably there was evolutionary pressure on the plants that were used medicinally. I can't believe that for thousands of years they were using these herbal treatments, and in their view accumulating empirical knowledge, without any evidence of the herbs working. Total delusion?

Aspirin came from tree bark, which people used to suck for headaches.

Mastic Gum, which is produced only on the southern end of the Greek Island Chios, was cited by Hippocrates, Galen and Columbus. The people in these "Mastic Villages" have been cultivating the trees for millennia. You can plant the tree elsewhere and it will produce gum, but it doesn't have medicinal properties.

Ginseng was so widely used that there is very little "real" Ginseng, and it's in a couple of places in the United States
where harvesting is closely regulated. "Real Ginseng" means Ginseng that is growing there naturally. Second best is Ginseng planted on ground where Ginseng once grew but was overharvested. Last is: just put some Ginseng in the ground and grow it. My acupuncturist gave me "real Ginseng" and it improved my energy. The ginseng most people take is junk.

I am not suggesting that you are arrogant, but I do think Western medicine has been arrogant in the view that there's nothing to be learned from Eastern Medicine.

Again, my view is that certain herbal remedies can help - as an adjunct to Western Medicine.

In a couple of months I will put up a post celebrating my five year mark [survival rate 30%]. My starting PSA was 240 and I had numerous bone mets, including distant ones. I was classed as "high volume" advanced PC. I think it's best to fight this beast on every front -- weight, exercise, diet, being involved in your medication decisions, and attitude. I have no delusions. This will kill me eventually, but I'm going to make it work for it.
Posted 11/21/2021 5:27 PM (GMT 0)
ANB: I suggest there is a difference between eating a healthy diet once diagnosed--along with exercise, etc--to aid in the process of treatment. Absolutely.

I just tend to get more an eyebrow raise when I see a claim that says, "THIS new diet/supplement/miracle thing will PREVENT cancer." It's not that simple. In many cases, cancer prevention is a matter of luck, genetics, and where you live and work.

What I find more interesting are the longitudinal studies that are trying to ask why certain people, or certain families have more cancer in them than others do.
Posted 11/21/2021 6:13 PM (GMT 0)
I agree
Posted 11/21/2021 9:29 PM (GMT 0)

halbert said...
ANB: I suggest there is a difference between eating a healthy diet once diagnosed--along with exercise, etc--to aid in the process of treatment. Absolutely.

I’ve been a vegetarian, mostly vegan, for over 40-years, primarily as a preventative against the family history of cardio disease, to which I added exercise (distance runner: marathons and such), meditation, and avoidance of vices. Guess what? Arteries are clear, low cholesterol, resting heart rate of 48, and have outlived most males on the family tree. I call my lifestyle a success for the cardio issue. BUT, I drew an unlucky card and I had prostate cancer. What the lifestyle did was make recovery from treatment a breeze.
Posted 11/22/2021 12:32 PM (GMT 0)
VinceinMT: I'm inspired by your vigilance (and results!). That is impressive self-discipline. Something to aspire to.
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