How Concerned Should I Be?

I haven't posted for quite a while as things have gone well considering original dx of Gleason 10. After lupron and radiation my PSA was undetectable for over 3 years. Went off Lupron after being undetectable for 1 1/2 years. Since 10/20 PSA has been detectable and rising. My Oncologist said he wouldn't be concerned until PSA was 1.0. Radiation Oncologist said treatment wouldn't be considered a failure until PSA was over 2. I'm wondering if my PSA is returning to normal or increasing due to prostate cancer. Going off Lupron was like getting my life and physical health back. Would hate to go back on it. Wondering how concerned I should be and what action I should consider.

4/14 PSA 2.47
11/3/14Kidney Transplant put on immune suppressing drugs
7/14/16 PSA 9.22, 9/6/16 PSA 12.7
12/29/16 Biopsy 11 of 12 cores show cancer Gleason 10
1/6 CT scan and bone scan, cancer in lymph nodes not in bones (immune suppressing drugs may have caused lymph nodes to enlarge)
1/13/17 started on Casodex, PSA - 28.5, 1/27/17 6 mth Lupron shot
2/17 Immune suppressing drugs reduced
6/12/17 <.06 Undetectable
6/17-7/17 39 imrb radiation treatment
Zytiga 7/17-1/18
PSA Undetectable 6/17-10/20
PSA 10/20-.06, 2/21-.09, 4/21-.16, 6/21-.19, 8/21-.21, 9/21-.25, 1/22-.47, 4/22-.89

After treatment PSA doesn’t return to whatever was normal. With radiation as the initial treatment the nadir plus 2 is the alert point. If I were a G10, I would take any increase as an alert to get after it. Remember, G10 expresses very little and sometimes no measurable PSA. I agree with Compiler that you should start looking for Mets and not to wait.