Bob,
The relationship between prostate surgery, trimix, and Peyronie's Disease is complicated and no one is entirely sure how it works. For one thing, nobody knows whether the injections cause PD, or whether a certain percentage of men who are impotent after prostate surgery develop PD from the poor blood flow and the injections make them notice it. Until the plaques get really bad PD is mostly noticeable to a man when he gets an erection. In many cases the erections a man gets from the injections will be the first he has had since surgery. This is made even more confusing by the dose titration for the injections. Men start with a relatively small dose and work their way up until they get a satisfactory result. If that first really hard erection reveals a PD curvature some men will tend to blame it on those first few jabs. Something like 10 to 15 percent of men who use injections for ED after prostate surgery will later complain of Peyronie's disease. There are some men who report a severe curvature with their first injections -- their disease was clearly not caused by the injection -- and there are men who use injections successfully for years before developing PD -- their disease is likely to result from scarification from the needles -- but for most men it's hard to decide. Here's a discussion:
https://www.urotoday.com/recent-abstracts/men-s-health/peyronie-s-disease/42293-beyond-the-abstract-peyronies-disease-following-radical-prostatectomy-incidence-and-predictors-by-raanan-tal-md-et-al.htmlOne thing to remember is that men who are candidates for injections are also candidates for implants. Which way you go is a matter of personal preference -- something of a flip-a-coin proposition. I think it makes sense to start with injections but if you start to develop Peyronie's Disease then you might want to turn that coin over and go with tails. Implants are a good treatment for early-stage PD and they treat ED about
as well as trimix.