halbert said...
I suspect most of us were diagnosed following PSA testing--I had annual PSA for over 5 years then a climb began that ended with diagnosis. DRE doesn't diagnose much PC.
I may have been an exception. I had a long series of (negative) biopsies for a slowly increasing PSA (from BPH) over many years with yearly uro visits. My uro noticed an induration on one side that he said did not require another biopsy, but did need to be followed, and he changed me to 6-month visits. A few visits later he noticed a new nodule on one side along with a PSA increase slightly higher than expected from my BPH (the induration on the other side had disappeared BTW) .
The biopsy found that the nodule was not cancer, but G9 and G10 cancer was found in 2 cores in other zones (14 cores total). Some time after my treatment (RP) I asked my uro/surgeon if he would have insisted on that last biopsy if I had just that size PSA increase (3.6 to 4.3 on finasteride) but no nodule. He looked at my history on his laptop screen, shook his head side to side, and said "We certainly would have discussed it."
Knowing myself, I would have said yes (as I always did over the years) to any of my uros suggesting I should have another biopsy. This is why I say that I may have been an exception.
Monitoring men with a history of BPH and a rising PSA for PCa can be tricky.
Djin