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PSA post Treatment 0.29 is good indication?

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Posted 12/12/2023 6:14 PM (GMT 0)
Hi, I went through 2 HDR Brachytherapy, 33 IGRT, 6 months Lupron. My last shot of Lupron was in August 21, my first 3 months of PSA is 0.29 from 7.9 post treatments.
Posted 12/12/2023 6:48 PM (GMT 0)
Looking good, Dave.
Michael
Posted 12/12/2023 7:02 PM (GMT 0)
Mike, since my last shot of Lupron in August 21 so it should be worn off by November 21. My question how long does it take for it completely out of my system and have true psa number? btw my first T level is 12.. how long does it take to recover to normal level by general?


Thanks
Posted 12/12/2023 11:30 PM (GMT 0)

dave1803 said...
Mike, since my last shot of Lupron in August 21 so it should be worn off by November 21. My question how long does it take for it completely out of my system and have true psa number? btw my first T level is 12.. how long does it take to recover to normal level by general?


Thanks


No that's not correct. Presumably you had a 3-month dose. T should remain low during the entire 3-month period.
See Fig 9 in
https://www.rxabbvie.com/pdf/lupronuro_pi.pdf

After that T is supposed to (!) rise again, but this is dependent on multiple factors. Could be slow, fast or never. This report has some recent data from the HERO study:
https://ascopubs.org/doi/abs/10.1200/jco.2022.40.6_suppl.104#:~:text=background%3a%20in%20the%20phase%203,11.8%3b%20p%20%3C%200.001%5d).
Of course, there are many other studies with T recovery data after Lupron has been halted.

Post Edited (Sr Sailor) : 12/12/2023 3:52:24 PM (GMT-8)

Posted 12/13/2023 12:02 AM (GMT 0)
Thank you Sr. Sailor,
I supposed to see my enologist on December 18th, I have my first blood draw about a week ago, so i will have few questions to ask him. Thank to Quest Lab App that i've installed on my phone so i can login and see my results before hand

But if anyone have any insight about :

1. What is the Psa drop prior and post treatment to indicate the effectiveness of the treatment.. like with in certain point of PSA.
2. I know i am going to experiences some kind of bounce in the coming months or year. How is you can identify it's a bounce vs rise of cancerous .
3. Is there any help to boost the T naturally?

Thanks for any input.

Dave

Post Edited (dave1803) : 12/12/2023 4:13:53 PM (GMT-8)

Posted 12/13/2023 1:28 AM (GMT 0)
I agree with 60Michael that this result looks good. Maybe very good!
Your PSA went way down, as it should have, and it may go down further. Although there are papers and people that pay a lot of attention to how fast the decline is, I think you should focus on the fact that your PSA went down significantly. Hopefully, in the long run it will settle to something less than 2 ng/mL, but this may take years. And yes, a bounce is certainly possible but there's no reason to worry about that now.
At the moment you should just rejoice. Do get T levels as well though along with the PSA tests; it will make it easier to see how your recovery is going.

Hopefully, others will add info about boosting T 'naturally'.
Posted 12/13/2023 2:36 AM (GMT 0)

dave1803 said...
Thank you Sr. Sailor,
I supposed to see my enologist on December 18th, I have my first blood draw about a week ago, so i will have few questions to ask him. Thank to Quest Lab App that i've installed on my phone so i can login and see my results before hand

But if anyone have any insight about :

1. What is the Psa drop prior and post treatment to indicate the effectiveness of the treatment.. like with in certain point of PSA.
2. I know i am going to experiences some kind of bounce in the coming months or year. How is you can identify it's a bounce vs rise of cancerous .
3. Is there any help to boost the T naturally?

Thanks for any input.

Dave

1) they used to say a slow drop meant a better likelihood of a "cure". you can see 14 years of my post lupron PSAs in my signature

2) only time will tell -- again look at my PSA history

3) ****hub? seriously have you had testosterone tested? i believe my doctor didn't test PSA until my testosterone returned -- and i went from like .7 to 700s in textbook time

i'd say you have a great first number. i'd tell you not to worry but i know i did and that's part of the deal with prostate cancer and radiation as a primary treatment. good luck man!
Posted 12/13/2023 10:17 AM (GMT 0)
The time to start measuring decrease in systemic ADT is from the effective length of the last shot, ie August plus three months. From that point it is has a half life of that period. So, it is in your system for several more months and can continue to suppress testosterone. The only way you really know is by measuring your Testosterone with a blood test. After about six months you should see it rising past castrate levels and returning to normal range over a year or so for many men. With a return to normal T, most men will also start expressing some PSA either from benign prostatic tissue and/or from PCa. Hopefully, your’s will only be from benign prostatic tissue.

Now that you are off ADT, your PSA will help you understand the effectiveness of the radiotherapy. So long as it stays under the “nadir plus 2.0” level, you are presumed to be free of PCa. You can expect the PSA to bounce around in the 18-36 month range and it can take some men five or more years to really see where the PSA settles in.
Posted 12/13/2023 12:48 PM (GMT 0)
My simple observation of other’s posts is that PSA is pretty much meaningless for a long period after primary ADT and RT unless totally out of whack. Just look up PSA bounce if you want to see RT patients freak out after a couple of years due to PSA variations. RT plays the long game with PSA so settle back and consider your treatment a success until some compelling evidence tells you differently. PSA is looking good….
Posted 12/13/2023 3:57 PM (GMT 0)
Thank you all for the inputs!!!
So far i have very minimal side effects from all the treatments, except hot flashes here and there but less and less every day now. Hopefully it can stay low as much as possible.
This forum is a god send and it helped me learn a lot.
Y'all have a nice day!

Dave
Posted 12/18/2023 10:30 PM (GMT 0)
You had triple play. i had double play, HDR Brachy/IMRT Boost see my PSA tracking without the ADT.

I would think your PSA will rise once the ADT wears off, to what degree?? Taken me over 4 years to get to 0.2
Posted 12/19/2023 8:38 PM (GMT 0)

Turboz said...
You had triple play. i had double play, HDR Brachy/IMRT Boost see my PSA tracking without the ADT.

I would think your PSA will rise once the ADT wears off, to what degree?? Taken me over 4 years to get to 0.2

I just met with my Oncologist yesterday, He did told me take at least 6 months for the Lupron to be out of my system completely, he did said most likely (like you stated) i will have some rise with the PSA but hopefully not much rise. So my next second PSA and testosterone will be what we are base on (since I only on ADT 6 months).

After all by reading alot of post in this forum, i realized that i will have some kind of bouncing fun with PSA for sure.

Thanks for your feed back!
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