BillyBob@388 said...
mattam said...
PS,
I forgot to add that I just wish that BAT (Bipolar Androgen Therapy) was developed to point of being a routine therapy for castrate sensitive patients. Wouldn't it be a hoot to get supraphysiologiical doses of T part of the time.😀
It would be the hootiest of hoots. I took papers describing this approach to my PC docs/NPs when 1st starting ADT a bit over 2 years ago. They had never heard of it then, and still have not as of a few months ago. I go for my 3 month check up tomorrow and will bring it up again.Hey BillyBob,
Hope you're doing well enough. Are you familiar with Morgentaler? He's a T guy at Harvard and bona fide researcher. I listened to him on a pod cast yesterday. He believes that TRT isn't a big deal. He kept saying that T below 250 and above 250 is bad afas PCa, but right around 250 is okay. For me (Lupron fog) he was jumping all over the place. But for those interested in TRT his papers and the Traverse trial may be worth looking into.
More specific to you Billy Bob. You might ask your Docs about
the Enzalutamide Embark Trial "protocol.";They Compared Lupron mono-therapy, Enzalutamide mono-therapy, and Lupron/Enzalutamide combination therapy. An an aspect of trial not much discussed is Intermittency. At week 37 any participant in any of the 3 arms who is undetectable, the treatment is withdrawn until a predetermined PSA returns. Those in the Combination arm averaged 20 months with no drugs. The data is still coming in and I don't remember if the protocol is to continue the cycling on and off the ADT. Presenting something to the MO, it's nice to have printed research in your hands. The paper is in the NEJM from last Nov. If you sign up with them they will let you download 2 articles per month no charge.
I'm sure getting tired of ADT too. Sooner or later I may talk to my MO about
some kind of relief plan. Good luck at your appointment.