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My first Lucrin (Lupron) Injection

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Posted 9/4/2011 4:21 PM (GMT 0)

I had my first  Lucrin (Lupron) injection a month ago (7.5 mg) and my PSA has come down from 3.2 to 0.4.

Should I be happy with that?

Cheers

Posted 9/4/2011 4:41 PM (GMT 0)
I would be estatic! Yes yes! Be happy!

Bud
Posted 9/4/2011 5:28 PM (GMT 0)
that is an awesome result so yes you should be REAL happy

peace to you
Dale
Posted 9/4/2011 5:48 PM (GMT 0)
To reiterate what has been said you have a very good response to the lupron.

Don
Posted 9/4/2011 7:19 PM (GMT 0)
According to Dr Strum and a few other oncologists you should see a reduction to .05 and remain there for at least 3 months. Patients with this response usually have a very favorable long term outcome while on HT. What is your "T"? This is important as it must be at least <20 to get a favorable HT resopnse.
Posted 9/5/2011 10:46 AM (GMT 0)

My T is 0.4 nmol/L or 11.46 ng/dl.

Cheers

Posted 9/5/2011 2:30 PM (GMT 0)
pk5

Your response after 1 month is excellent, even moreso. After 6 months on Zoladex and six months off my PSA remains at <.04 and my T levels remain at .7 nmol/L. (Units of Measure - Are you Canadian?). You should be over the moon right now with those results. The HT is definitely doing its job.  Any SE's as of the first month?

Jack

Posted 9/5/2011 2:44 PM (GMT 0)

Hi Skate

I'm in Australia.

No SE's so far!

Cheers

Posted 9/6/2011 1:32 PM (GMT 0)
I went from PSA 59 to <.1 in about 90 days and have held at <.1 foor about 11 nonths now. My next PSA test will be Oct 7. My T level was 23 at 90 days and was less than 3 at six months. I was given ADT3 so we had all guns blazing. I understand that with that approach PSA drops very quickly. My oncologist said in January that after just 60 days on HT he wouold expect to see the PSA be undetectible.

As John T said, the key is a quick drop to a low point (nadir) and then hold that point for at least several months. Studies show that response is indicative of a longer more durable remission, and sometimes a cure.
Posted 9/7/2011 3:25 AM (GMT 0)

Is a cure still possible?!

Cheers

Posted 9/7/2011 11:27 AM (GMT 0)
So, although there might be some anectdotal cases of cures with HT therapies and anything is possible, this is not a one trick pony disease, many variations and types and even DNA structures, let alone the Gleason scores or missed biopsies info that is unknown.

Some people do way better than others, it is all about control.
Google search for Dr. Fred Lee (cryo inventor doc) whom was diagnosed with PCa like 27 yrs. ago now, he failed cure 25+ yrs. ago and is still working and alive...of course his drug choice is considered 'stupid' by some of the so called experts.

So far your response is typical of most or many patients. Now if it did not effect psa level that would be very worrisome early on with PCa.  The good news is you can very well get a long term control and like many other patients, never die from PCa, but could from heart disease and other old age ailments, so consider that a goal perhaps.  You should be under the advice of an oncologist as monitoring psa is not the only variable to watch.

Post Edited (zufus) : 9/7/2011 5:39:53 AM (GMT-6)

Posted 9/7/2011 12:24 PM (GMT 0)

Thanks zufus

I understand your comments I only asked because JNF mentioned "a cure" in his post.

Cheers

Posted 9/8/2011 4:42 PM (GMT 0)

John T said...
According to Dr Strum and a few other oncologists you should see a reduction to .05 and remain there for at least 3 months. Patients with this response usually have a very favorable long term outcome while on HT. What is your "T"? This is important as it must be at least <20 to get a favorable HT resopnse.

Is there any reason to worry about "T" if one has had an obvious favorable response from HT? I have been on HT since August 2009 and my PSA has basically been in the undetectable level for over an year. I am going off HT now. My last 3-month Lupron injection was in July 2011, and I discontinued Casodex and Avodart two weeks ago. My oncologist says there is no justification for the test now because even if it showed low "T" he would not recommend a "T" boost for someone with high risk PCa.

Sancarlos
Posted 9/9/2011 12:18 AM (GMT 0)
Hi, that is indeed a good result, very interesting to me as I may be doing HT soon, hope all goes well, by the way noticing that you are in Australia, is the Lupron subsidized by the PBS or do you pay the full cost?

Regards Mal.
Posted 9/9/2011 1:14 PM (GMT 0)

Hi maldugs

Lupron is subsidized by the PBS.

Cheers

Posted 9/10/2011 12:00 AM (GMT 0)
Thanks mate.

Mal.
Posted 9/10/2011 8:27 AM (GMT 0)
You should be very happy tongue
Posted 9/10/2011 8:50 AM (GMT 0)
Lupron is only pallative, don't forget.
Posted 9/10/2011 9:11 AM (GMT 0)
Keep a positive attitude, it works for me.
Posted 9/11/2011 2:05 AM (GMT 0)
Dr. Snuffy Meyers considers HT as a curative in many situations. Officially, (FDA drug disclaimers) HT is pallitive but when you see people go 10-15-20 years after diagnosis it helps us understand that a lot of these treatments can keep us going for a long time.

I re-read your signature and see the T3 and G9 which are certainly high risk. You can see by my signature that we are the same age and I am high risk as well (my PSA).

I hope you have one of the great PCa oncologists on your team that will use the treatments that get ahead of the cancer rather than reacting to a PSA rise. I would think that you might be looking at combining some chemo with HT at this point or considering other alternatives. Clearly it is imperative to jump all over the PCa at this point.

My concern is a PSA rise and what I will do. I will have a PSA test in 30 days and hope to see another undetectible. If I have a rise, I have decided that I will quickly go to either Meyers in Virginia or Oliver Sartor at Tulane. Both are a day's drive away as I am in Atlanta. I am hopeful that it will be far enough in the future that Meyers is retired as he is more than 10 years my elder.
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